摘要
目的探讨雷公藤在类风湿性关节炎治疗中的临床疗效及安全性。方法随机将146例类风湿性关节炎患者分为观察组74例、对照组72例。观察组口服雷公藤片治疗2片/次、每日3次,对照组口服甲氨蝶呤治疗10 mg/次、每周1次,均连续用药3个月。结果观察组治疗后晨僵时间、压痛关节数、肿胀关节数和平均握力均较对照组有明显改善(P<0.05或P<0.01)。观察组不良反应发生率明显较对照组低(χ2=4.80,P<0.05)。结论雷公藤片治疗类风湿性关节炎,能显著改善患者的临床症状、体征,且不良反应相对较少。
Objective To explore the clinic effect and safety of tripterygium wilforddi hook on rheumatoid arthritis.Methods 146 cases of rheumatoid arthritis were randomly divided to observation group（n=74） and control group（n=72）.The observation group were treated by tripterygium wilforddi hook,and the control group were treated by methotrexate.Results There were significant difference in the time of morning stiffness,the joint number of pressing pain,the joint number of swelling and the average of gripping（P 0.05）.There were also significant difference in the rate of adverse reaction（χ2=4.80,P 0.05）.Conclusion Tripterygium wilforddi hook would improve the symptom and sign in patients of rheumatoid arthritis,reduce the rate of adverse reaction,worthy of clinic spreading.
出处
《中国药业》
CAS
2011年第14期76-77,共2页
China Pharmaceuticals
关键词
类风湿性关节炎
雷公藤
甲氨蝶呤
rheumatoid arthritis
tripterygium wilforddi hook
methotrexate
