摘要
目的观察短期大剂量应用通心络胶囊对不稳定性心绞痛血清炎性因子[肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)]的影响。方法将不稳定性心绞痛71例随机分为2组。对照组35例予不稳定性心绞痛常规药物治疗,通心络胶囊2粒,每日3次口服;治疗组36例在对照组治疗基础上予通心络胶囊6粒,每日3次口服。2组均以8 d为1个疗程。分别于治疗前后测定血清TNF-α、IL-6、hs-CRP,同时检测肝功能、肾功能、凝血功能和血脂相关指标。结果治疗组治疗后血清TNF-α、IL-6、hs-CRP与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.05),对照组治疗后血清TNF-α、IL-6、hs-CRP与本组治疗前比较差异均无统计学意义(P>0.05),治疗组改善优于对照组。2组治疗后肝功能、肾功能、凝血功能及血脂相关指标与本组治疗前及组间比较差异均无统计学意义(P>0.05),2组改善均不明显。结论短期大剂量口服通心络可有效抑制不稳定性心绞痛患者血清炎性因子的产生和稳定斑块,有可能减少心脏事件的发生。
Objective To investigate the effect of the short-term high-dose Tongxinluo on serum levels of tumor necrosis factor alpha（TNF-α）,interleukin-6（IL-6）and high-sensitive c-reactive protein（hs-CRP） in patients with unstable angina.Methods 71 patients of unstable angina were in our hospital from July 2008 to February 2010 who were randomly divided into two groups： control group（n=35） received conventional drug therapy of unstable angina in taking Tongxinluo capsule 2 pills,three times a day,and Tongxinluo group（n=36） on the basis of conventional drug therapy in taking Tongxinluo capsule 6 pills,three times a day for 8 days.The serum levels of TNF-α,IL-6,hs-CRP,liver and kidney function,blood coagulation function and lipids were measured before and after treatment.Results There were obvious differences between two groups on the serum levels of TNF-α,IL-6 and hs-CRP after treatment（P0.05）.The improvement of TNF-α,IL-6 and hs-CRP in Tongxinluo group was superior to that in control group.There was no significant difference in liver and kidney function,blood coagulation function and lipids between two groups and before and after treatment（P 0.05）.Conclusion The application of short-term high-dose Tongxinluo can inhibit effectively the producing of inflammatory factors,stabilize atherosclerotic plaque and may decrease the occurrence of heart incident in patients with unstable angina.
出处
《河北中医》
2011年第6期904-906,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
心绞痛
不稳定型
中药疗法
心血管药物(中药)
胶囊
C反应蛋白质
白细胞介素6
肿瘤坏死因子α
Tongxinluo
Therapy of traditional Chinese medicine
Cardiovascular medicine
Capsule
Unstable angina pectoris
Tumor necrosis factor alpha
Interleukin-6
C-reactive protein
