达英-35与二甲双胍治疗伴胰岛素抵抗型多囊卵巢综合征性不孕症的疗效观察被引量：3

下载PDF

导出

摘要目的观察达英-35联合二甲双胍治疗伴胰岛素抵抗(IR)型多囊卵巢综合征(PCOS)性不孕症的临床效果。方法收集2008年10月～2010年4月PCOS伴IR不孕患者68例,随机分成两组,每组各34例。治疗组应用达英-35联合二甲双胍治疗;对照组单独应用达英-35治疗。两组患者均治疗3个周期后促排卵。观察两组患者治疗前后激素水平、胰岛素水平及促排卵结局。结果两组患者治疗后血清睾酮较治疗前明显降低;治疗组应用二甲双胍治疗,能够较好的治疗患者的胰岛素抵抗,并能在一定程度上控制患者的血糖水平,对照组治疗前后血糖及胰岛素水平无明显变化;治疗后治疗组妊娠率较对照组增高。结论达英-35加二甲双胍治疗胰岛素抵抗型多囊卵巢综合征性不孕可以明显提高妊娠率。

作者周啟萍

机构地区云南省昭通市中医医院

出处《中国医学创新》 CAS 2011年第19期50-51,共2页 Medical Innovation of China

关键词多囊卵巢综合征达英-35 二甲双胍促排卵

分类号 R711.75 [医药卫生—妇产科学]

引文网络
相关文献

参考文献4

1初永丽.PCOS与胰岛素抵抗研究进展[J].国外医学（妇幼保健分册）,2002,13(4):145-147. 被引量：17
2陈子江,李媛,周灿权,黄荷凤,刘嘉茵,乔杰,黄国宁,梁晓燕,郁琦.多囊卵巢综合征与辅助生殖的热点问题讨论[J].现代妇产科进展,2004,13(4):241-250. 被引量：58
3夏舟岚,华凯.二甲双胍在多囊卵巢综合征中的作用[J].国外医学（妇产科学分册）,2004,31(2):73-76. 被引量：42
4陆湘,汪玉宝,张炜,薛晓红.达英35对非肥胖、非胰岛素抵抗多囊卵巢综合征胰岛素敏感性的影响[J].实用妇产科杂志,2004,20(6):340-342. 被引量：25

二级参考文献47

1Legro RS,Finegood D,Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab, 1998,83(8):2694-2698.
2Falsetti L, Gambera A, Tisi G. Efficiacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine,clinical and ultrasonographic profile in polycystic ovarian syndrome. Hum Reprod, 2001,16(1):36-42.
3The ESHRE Capri workshop group. Ovarian and endometrial function during hormonal contraception. Hum Reprod,2001,16(7):1527-1535.
4Armstrong VL, Wiggam MI, Ennis CN et al. Insulin action and insulin secretion in polycystic ovary syndrome treated with ethinyl oestradiol/cyproterone acetate. Q J Med,2001 ,94:31-37.
5Dahlgren E, Landin K, Krotkiewski M,et al. Effect of two antiandrogen treatment on hirsutism and insulin sensitivity in women with polycystic ovary syndrome. Hum Reprod,1998,13(10):2706-2711.
6Pandit MK, Burke J, Gustafson AB,et al.Drug-induced disorders of glucose tolerance. Ann Intern Med,1993,118(7):529-539.
7Segal KR,Landt M, Klein S. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes ,1996,45:988-991.
8La Marca A, MorganteG, Palumbo M, et al. Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome. Fertil Steril,2002, 78(6): 1234-1239.
9Vrbikova J, Hill M, Starka L, et al. The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polvcvstic ovary syndrome. Eur J Endocrinol, 2001, 144(6):619-628.
10Arslsnian SA, Lewy V, Danadian K, et al. Mefformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab, 2002, 87(4): 1555-1559.