摘要
目的探讨舒利迭（吸入型肾上腺皮质激素与长效β2受体激动剂的预混制剂）联合双水平气道正压通气（BiPAP）对稳定期重度慢性阻塞性肺疾（COPD）的治疗作用。方法重度稳定期COPD病人40例,随机分为两组,A组舒利迭50ug/500ug,1吸/次,2次/d;BiPAP,吸气压力（IPAP）10-20cmH20,呼气压力（EPAP或PEEP）3-5cmH2O,吸氧浓度（FiO2）2L/min,每天夜间通气6-8h。B组仅用舒利迭,观察治疗前、治疗后12周病人临床症状、生活质量、健康状态和肺功能。结果治疗前、治疗后12周病人的临床症状、严重程度、健康状态和生活质量、肺功能等指标比较差异有统计学意义（P〈0.05）。结论舒利迭联合BiPAP治疗重度稳定期COPD病人较单用舒利迭更能能够明显改善其症状及肺功能,提高生活质量,对减缓COPD病人肺功能下降、延长病人生存时间有积极意义。
Objective To investigate the treatment effect of seretide accuhaler（mixture preparation of long-acting β2-agonist and inhaled corticosteroid）combined with BiPAP on severe COPD patients at stable stage.Methods Forty COPD patients at stable stage were randomly divided into two groups,group A was treated with seretide accuhaler 50/500ug by accuhaler/diskus,2 times per day,and BiPAP（IPAP 10～20cm H20,EPAP 3～5cm H20,Fi02 3L/min）6～8h every night.Grpup B was treated only by seretide.After 12 weeks,clinical symptoms,quality of life and lung functions were evaluated before and after treatment.Results After 12-weeks treatment,the observed indexes were significant improved（P0.05）.Conclusion Using BiPAP ventilation with seretide in treatment of severe and very severe COPD patients has better effect than the single use of seretide therapy,it improves lung function and quality of life.
作者
黄超群
HUANG Chao-qun（Department of respiratory,traditional hospital of suining city of Sichuan province,Suining 629000,China）
出处
《医学信息》
2011年第13期4179-4181,共3页
Journal of Medical Information
