期刊文献+

多药耐药基因1C3435T多态性与癫痫耐药的关联性研究 被引量:1

Association of C3435T Polymorphism in Multidrug Resistance Gene 1 with Refractory Epilepsy
原文传递
导出
摘要 目的:探讨我国癫痫患者P-糖蛋白基因多态性(C3435T)与抗癫痫药物反应性的关联性。方法:采用PCR--RFLP(聚合酶链反应--限制性片段长度多态性分析)的方法对156例癫痫患者外周血进行分型。其中,耐药组癫痫患者85例,有效组癫痫患者71例。结果:耐药组癫痫患者CC基因型21例,占24.70%;有效组癫痫患者CC基因型19例,占26.76%。两组比较无显著差异性。结论:本研究未发现P-gp C3435T基因型与癫痫耐药的关联性。 Objective: To discuss the association between the P-glycoprotein gene polymorphism and the efficacy of epilepsy drug.Methods: Genotypes of the C3435T polymorphism were determined by the polymerase chain reaction restriction fragment length poly-morphism(PCR-RFLP) methods in 156 patients,Including refractory epilepsy group(85) and drug-responsive group(71).Results: In non responders,21 patients were CC genotype(24.70%).In responders,19 patients were CC genotype(26.76%).Conclusion: There is no as-sociation between the P-gp C3435T gene polymorphism and the response to antiepileptic drug treatment in Chinese patient with epilepsy.
出处 《现代生物医学进展》 CAS 2011年第14期2717-2719,共3页 Progress in Modern Biomedicine
关键词 P-糖蛋白 癫痫 基因多态性 P-glycoprotein Epilepsy Polymorphism
  • 相关文献

参考文献19

  • 1郑兴珍,武士京.难治性癫痫的耐药性与多药耐药基因的研究进展[J].神经疾病与精神卫生,2008,8(1):74-77. 被引量:12
  • 2Duncan JS, Sander JW, Sisodiya SM, et al. Adult epilepsy [J]. Lancet, 2006, 367(9516): 1087- 1100.
  • 3Borst P, Evers R, Kool M, et al. A family of drug transporters: the multidrug resistance-associ ated proteins [J]. J Natl Cancer Inst, 2000, 92 (16):1295-1302.
  • 4Brinkmann U, Roots I, Eichelbaum M. Pharmacogenetics of the human drug-transporter gane MDRI: impact of polymorphisms on pharmacotherapy [J]. Drug Discov Today, 2001, 6(16): 835-839.
  • 5Woodahl EL, Ho RJ. The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function [J]. Curr Drug Metab, 2004, 5(1):11-19.
  • 6Loscher W, Klotz U, Zimprich F, et al. The clinical impact of pharmacogenetics on the treatment of epilepsy [J]. Epilepsia, 2009, 50(1): 1-23.
  • 7吴逊,沈鼎烈.难治性癫痫[J].中华神经科杂志,1998,31(1):4-4. 被引量:133
  • 8Siddiqui A, Kerb R, Weale ME, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 [J]. N Engl J Med, 2003, 348(15): 1442- 1448.
  • 9Ak H, Ay B, Tanriverdi T, et al. Expression and cellular distribution of multidrug resistance- related proteins in patients with focal cortical dysplasia [J]. Seizure, 2007, 16(6):493-503.
  • 10Aronica E, Ozbas-Gerceker F, Redeker S, et al. Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development [J]. Acta Neuropathol, 2004, 108(5):422-434.

二级参考文献23

  • 1付永娟,朴月善,卢德宏.难治性癫的神经病理学特点[J].卒中与神经疾病,2006,13(1):62-64. 被引量:7
  • 2郑雪平,谭兰,宋敬卉,王雁,孙妍萍,朱琪秀.难治性癫患者外周血中MDR1基因的表达及临床意义[J].中国神经精神疾病杂志,2006,32(5):454-456. 被引量:9
  • 3Tishler DM,Weinberg KI, Hinton DR, et al. MDR1 gene expression in brain of patients with medically intractable epilepsy [J]. Epilepsia, 1995,36(9):1-6.
  • 4Hoffmeyer S, Burk O, Richter O, et al. Functional polymorphisms of the human multidrug resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo[J]. Proc Natl Acad Sci, 2000,97(6) :3 473-3 478.
  • 5Haimeur G,Conseil RG,Deeley, et al. The MRP-related and BCRP/ABCG2 multidrug resistance proteins: substrate specificity and regulation current drug metabolism[J]. Biology, 2004, 21(5) :21-53.
  • 6Rosenberg M F, Callaghan R,Ford R C, et al. Structure of the Multidrug Resistance P-glycoprotein 2. 5nm Rosolution Datermined by Electron Midroscopy and Image Analysis[J]. J Biol Chem, 1997,272(16):10 685-10 694.
  • 7Ling V. Multidrug resistance: molecular mechanisms and mlinical relevance[J]. Cancer chemother pharmacol, 1997,40(1):3-8.
  • 8Ueda K, Taguchi Y, Morishima M. How does P-glycoprorein recognize its substrates? [J]. Semin Cancer Biol, 1997,45 (8):424 -429.
  • 9Silvio Basic, Sania Hainsek . Comment letters[J]. Epilepsia, 2006,47(2):449- 452.
  • 10Ying Wang-Tilz, Christian Tilz, Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy[J]. Epilepsia, 2006,47(2) :223-239.

共引文献143

同被引文献8

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部