摘要
目的 为了探讨男性甲亢患者药物治疗后缓解较慢的原因.方法 通过用放免法测定患者血清β2-MG,TGMb、TMAb的含量变化,将172例男性甲亢患者根据治疗过程分为三组,即初发组（B组,68）,未缓解组（C组,55）,缓解组（D组,49）;61名正常人作为对照组（A组）.结果 甲亢B组与C组血清β2-MG,FT3,FT4水平明显高于A组（P〈0.01）,而TGAb,TMAb的阳性率明显下降（P≤0.01）,B组与C组FT3,FT4与β2-MG呈明显正相关,而缓解组β2-MG,FT3,FT4与A组相比,差别无显著性（P〉0.05）,D组与C组相比,TGAb,TMAb阳性率差别无显著性（P〉0.05）.D组22.69%的患者血清β2-MG仍明显增高,24.3%的患者TGAb,TMAb仍持续阳性.结论 血清β2-MG、TGAb,TMAb可作为男性甲亢免疫缓解指标,其检测值可以观察疗效,指导治疗.大约28%左右男性甲亢患者缓解较慢,可能是由于患者血清β2-MG持续增高,TGAb,TMAb持续阳性造成的.
Objective To Study the cause for slow recover）- in male hyperthyroidism patients after treated with ATD. Methods The changes of serum β2 - MG, TGAb and TMAb Were measured by RIA. A total of 172 male hyperthyroidism patients were diVided into 3 group by their different therapeutic effects ： untreated patients （ group B, n = 68）, treated but unrelieved patientS （ group C, n = 55 ）, treated and recovered patients（ group D, n = 49）, and 61 normal person serving as controls（ group A）. Results The resuns indicated that the levels of serum β2 - MG, FT3 and FT4 were significantly higher in group B and C than those in group A（ P 〈 0.01 ）, but the positive rates of TGAb and TMAb were notably lower than those in group A（P 〈 0.01）. There was a positive correlation between FT3 or Fr4 and β2 - MG respectively in group B and C .There was no Signincant difference in ~r2- MG, FT3 and FF4 between group D anid A（P 〉 0.05） .And there was no difference in the posi- tive rates of TGAb and TMA_b between grOup D and C（P〉 0.05）.The serum 182 - MG was still higher in 22.69% patients and the positive rates of TGAb and TMAb were also higher in 24.3 % patients. Conclusion These results suggest That β2 - MG, TGAb and TMAb could act as serum markers of immunological remission for male hyperthyroidism patients and the determination of β2 - MG, TGAb and TMAL could be benifical to monitoring therapeutic effect. The cause for slow recovery in about 28% male hyperthyroidism patients might be due to higher serum ~2 - MG and higher positive rates of TGAb and TMAb.
出处
《医学检验与临床》
2011年第3期21-23,共3页
Medical Laboratory Science and Clinics
