β-分泌酶2在散发性阿尔茨海默病发病机制中的作用
The role of β-site APP--cleaving enzyme 2 in the pathogenesis of sporadic Alzheimer＇s disease
摘要
阿尔茨海默病（Alzheimer’Sdisease，AD）是一种病因不明的、以认知功能障碍为主要特征的神经系统变性病，通常认为是遗传因素和环境因素共同作用的结果。AD作为老年期痴呆中最常见的类型，其发病机制并未完全阐明，有遗传易感性、淀粉样β蛋白（β-amyloid，Ap）毒性、氧化应激、炎症反应等多种学说。
出处
《神经疾病与精神卫生》
2011年第3期304-307,共4页
Journal of Neuroscience and Mental Health
参考文献33
-
1I;vatsubo T. Beta--amyloid cascade.- current status and future directions[M]. Rinsho Shinkeigaku, 2000,40 (12) : 1 228 - 1 230.
-
2Storey E,Cappai R. The amyloid precursor protein of Alzheimer's disease and the Abeta peptide[J]. Neuropathol Appl Neurobiol, 1999,25(2) :81-97.
-
3Steiner H,Cape!l A,Leimer U,et al. Genes and mechanisms in- volved in beta amyloid generation and Alzheimer's disease[J]. Eur Arch Psychiatry Clin Neurosei,1999,249(6):266-270.
-
4Bennett BD,Babu--Khan S,Loeloff R,et al. Expression analysis of BACE2 in brain and peripheral tissues[j]. J Biol Chem, 2000,275(27) :20 647-20 651.
-
5Acquati F,Accarino M, Nucci C, et al. The gene encoding DRAP(BACE2) ,a glycosylated transmembranc protein of the aspartic protease family,maps to the down critical region[J]. FEBS Lett, 2000,468 ( 1 ) : 59- 64.
-
6Selkoe DJ. Alzheimer's disease: a central role for amyloid[J]. J Neuropathol Exp Neurol,1994,53(5):438-447.
-
7Hendriks L,Van--Broeckhoven C. A beta A4 amyloid precur sot protein gene and Alzheimer's disease[J]. Eur Biochem, 1996,237(1) :6-15.
-
8Haass C,Selkoe DJ. Cellular processing of β -amyloid precur sor protein and the genesis of amyloid β- peptidei[J] Cell, 1993,75(6):1 039-1 042.
-
9Sisodia SS. Beta--amyloid precursor protein cleavage by a membrane- bound protease[J]. Proc Natl Acad Sci USA, 1992,89:6 075-6 079.
-
10Jarrett JT, Lansbury PT Jr. Seeding"One- dimensional crys tallization" of amyloid~ a pathogenic mechanism in Alzheimer's disease andscrapie? [J]. Ce11,1993,73(6):1 055 -1058.
-
1黑爱莲,蔡剑平.阿尔茨海默病动物模型的概况(综述)[J].中国神经免疫学和神经病学杂志,2005,12(4):223-225. 被引量：8
-
2于峰.微血管减压术治疗原发性三叉神经痛研究现状[J].实用医药杂志,2008,25(10):1258-1259.
-
3郑乃智,冯海燕,王敏,李筱瑜.胶质激活相关炎症与癫癎新治疗靶点[J].癫痫与神经电生理学杂志,2014,23(3):180-181.
-
4陈安强,缪中荣.短暂性脑缺血发作165例血管病变探讨[J].贵州医药,2005,29(4):340-341. 被引量：2
-
5朱遵燕,杨晓秋.神经肽与原发性三叉神经痛[J].重庆医学,2010,39(5):611-613. 被引量：4
-
6谢岚,艾华.运动对阿尔兹海默病影响的研究进展[J].中国运动医学杂志,2013,32(9):834-839. 被引量：9
-
7陆元方.Alzheimer病的相关因素分析[J].医学信息,2010,23(19):3665-3665.
-
8宋成军,尹长恒,高晓玲,田树森.血管性痴呆的中西医治疗现状和前景[J].承德医学院学报,2001,18(2):153-155. 被引量：1
-
9张强.阿尔茨海默病与免疫炎性反应[J].医学综述,2007,13(16):1250-1252. 被引量：6
-
10王淑英.老年痴呆的发病机理及药物治疗进展[J].洛阳医专学报,2002,20(3):266-268. 被引量：9
