摘要
目的观察三叶青水提物对小鼠痛经模型的影响。方法采用连续灌胃给药后,观察三叶青水提物对缩宫素诱发的小鼠离体子宫体平滑肌收缩及扭体反应的影响。结果发现三叶青水提物对缩宫素诱发的小白鼠扭体反应有较好的对抗作用（P〈0.01）;对正常小白鼠离体子宫平滑肌的收缩活动无明显影响,在浴槽终质量浓度为（50~200 mg/m l）时,具有抑制缩宫素诱发的子宫平滑肌的收缩功能（P〈0.05或P〈0.01）,且呈明显的剂量依赖性。结论三叶青水提取物可显著抑制缩宫素诱发的小鼠子宫收缩。
Objective To observe the therapy effects of extract from Tetrastigma hemsleyanum Diels et Gilg（TDG） on dysmenorrhea models in mouse. Methods Diethylstilbestrol and oxytocin were used to induce twisting body reaction and contraction of isolated uterus of the mice.Then different dosages of extract from TDG extraction were applied to study their effection on these reactions induced by diethylstilbestrol and oxytocin.Results Extract from TDG extraction reduced the tension of isolated mouse uterus stimulated by oxytocin（P0.05 or P0.01）.It also markedly decreased the amount of mice which had tortility and the number of twisting body（P0.01）.All the effects showed a dose-dependent manner.Conclusion Extract from TDG extraction had a good curative effect on mice dysmenorrhea models.
出处
《广州医药》
2011年第4期39-42,共4页
Guangzhou Medical Journal
关键词
三叶青
小鼠
离体子宫
扭体反应
Tetrastigma hemsleyanum Diels et Gilg
Mouse
Solated uterus
Twisting body reaction.
