摘要
目的 探讨食管癌（ＥＣ） 患者红细胞（ＲＢＣ） 免疫功能的改变。方法 选择１２５ 例高发区ＥＣ患者、５５ 名健康志愿者。比较患者组与常人组ＲＢＣ免疫功能；患者组以ＴＮＭ 分期、围术期分层比较。结果 患者ＲＢＣＣ３ｂ 受体花环率降低（ Ｐ ＜ ０ ．０５）；ＲＢＣ 免疫复合物花环率升高（ Ｐ ＜ ０．０５） ；血清ＲＢＣ免疫抑制因子含量增多（ Ｐ＜ ０．０５） ；ＲＢＣ免疫促进因子含量降低（ Ｐ＜ ０ ．０５） 。患者肿瘤ＲＢＣ花环，如直向肿瘤ＲＢＣ花环率、促肿瘤ＲＢＣ花环率、协同肿瘤ＲＢＣ 花环率、自然肿瘤ＲＢＣ花环试验均有降低（ Ｐ＜０ ．０５）。结论 ＥＣ患者ＲＢＣ免疫功能低下，其受抑程度与患者病变的早晚有关；手术可加剧这种改变。
Objective To study the changes and associated factors of red blood cell (RBC) immunity in cases of esophageal carcinoma (EC). Methods 125 patients with EC undergoing esophagectomy and 55 healthy people were recruited. The tests included RBC C3b receptor rosette (RBC C3b RR), RBC immune complex rosette (RBC ICR), natural tumor erythrocyte rosette (NTER), direct tumor erythrocyte rosette (DTER), associated tumor erythrocyte rosette (ATER), enhanced tumor erythrocyte rosette (ETER), RBC immune adherence enhance factor (RFER), RBC immune adherence inhibitor factor (RFIR). The comparison were done between the patients and the controls, perioperation, among different TNM stages. Results RBC C3b RR of the patients was lower than that of controls (P<0.05). RBC ICR of the patients was higher than that of controls (P<0.05). RFIR of the patients was higher than that of controls (P<0.05), but RFER decreased in the patients. NTER, DTER, ATER, ETER in the patients were lower than those in the controls. Conclusion RBC immunity functions were suppressed in the cases of EC, and its degree was associated with TNM stage of tumor. Surgery can enhance the disturbances.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第6期549-551,共3页
Chinese Journal of Experimental Surgery
基金
河南省科技攻关项目
