摘要
目的：研究Ⅰ型细胞间粘附分子（ＩＣＡＭ－１）ｍ ＲＮＡ 的表达与肝癌侵袭转移的关系。方法：采用原位分子杂交及Ｎｏｒｔｈ－ｅｒｎ ｂｌｏｔ方法检测３４例肝癌组织中ＩＣＡＭ－１ ｍ ＲＮＡ 的表达。结果：３４例肝癌中２４例包膜不完整、门静脉癌栓或形成转移灶，１０例肝癌包膜完整，３４例肝癌中２１例肝癌细胞ＩＣＡＭ－１ ｍ ＲＮＡ表达阳性。伴门静脉癌栓或形成转移的肝癌１８例中，１６例ＩＣＡＭ－１ｍ ＲＮＡ 表达（＋ ＋ ）～（＋ ＋ ＋ ）；６例包膜不完整的肝癌３例表达阳性，而１０例包膜完整的肝癌仅有２例表达阳性。门静脉癌栓及肝内转移灶ＩＣＡＭ－１ ｍ ＲＮＡ 表达强阳性。结论：肝癌细胞ＩＣＡＭ－１ ｍ ＲＮＡ 的表达与肝癌的侵袭转移相关。
Objective: To investigate the relationship between intercellular adhesion molecule 1(ICAM 1) mRNA expression and the hepatocellular carcinoma(HCC) invasion and metastasis. Methods: The ICAM 1 mRNA expression was analyzed in 34 HCC surgical specimens using in situ hybridization and Northern blot techniques. Results: The 34 cases of HCC were divided into 2 groups,twenty four HCC cases showed expansive growth pattern,such as direct invasion,portal cancer emboli as well as tumour satellites,and 10 cases have fibrous capsule. Twenty one HCC cases showed ICAM 1 mRNA positive expression. The ICAM 1 mRNA expression was stronger in metastatic HCC than in that of non metastatic HCC, and the metastatic lesions and portal cancer emboli showed strong positive expression. Conclusion: The ICAM 1 mRNA expression in the HCC cells may relate to the invasion and metastasis of HCC.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第10期740-742,共3页
Academic Journal of Second Military Medical University
关键词
肝细胞癌
肿瘤转移
ICAM-1
肿瘤侵袭
mRNA
adhesion molecule Ⅰ, intercellular
hepatocellular carcinoma
invasion
metastasis
