摘要
目的分析神经精神性狼疮(NPSLE)患者常见的临床表现并探讨其头颅MRI的特点及应用价值。方法回顾性分析11例经临床确诊的NPSLE患者的临床资料及头颅MRI检查结果。结果 11例患者中表现为狼疮样头痛8例,癫痫发作4例,言语不利3例,精神症状、视物模糊和偏瘫各2例,意识障碍和共济失调各1例。10例行头颅MRI检查的患者中,有6例出现异常信号影,病灶累及脑叶(额顶枕叶)3例,基底节2例,白质(皮质下白质、脑室旁及半卵圆中心)5例。病灶性质包括腔隙性梗死(4例)、脑血栓形成(3例)和脑萎缩(2例)。结论 NPSLE临床表现复杂多样,以狼疮样头痛及癫痫发作最常见;头颅MRI可发现NPSLE患者脑内病灶的部位及性质,是较为敏感的检查方法,结合临床可以协助诊断。
Objective To analyze the common clinical manifestations of the neuropsychiatric systemic lupus erythematosus （NPSLE）, and to investigate the features and the values of MRI findings. Methods Eleven cases of clinically confirmed NPSLE were retrospectively reviewed, their clinical information and MRI findings were analyzed. Results Of the 11 cases, there were eight different types of neuropsychiatric symptoms： lupus-like headache （8 cases）, seizure （4 cases） , speech disorder （3 cases）, psychosis （2 cases）, blurred vision （2 cases）, hemiparalysis （2 cases）, conscious disturbance （1 case） and ataxia （1 case）. 10 patients performed MRI and abnormalities were observed in 6 patients. The lesions were located in cerebral lobe （front/parietal/occipital lobe） （3 cases）, basal ganglion （2 cases）, and white matter （subcortical white matter, paraventricle, centrum semiovale） （5 cases）. The lesions showed three different characters： lacunar infarction （4 cases）, cerebral thrombosis （3 cases） and cerebral atrophy （2 cases）. Conclusions NPSLE showed various clinical manifestations, among which the lupus-like headache and seizure are the most common ones. MRI is sensitive in detecting cerebral lesions in aspects of their locations and characters in NPSLE, and together with the clinical features, it is helpful in the diagnosis of NPSLE.
出处
《中国神经免疫学和神经病学杂志》
CAS
2011年第4期287-289,共3页
Chinese Journal of Neuroimmunology and Neurology
关键词
狼疮血管炎
中枢神经系统
磁共振成像
lupus vasculitis, central nervous system
magnetic resonance imaging
