摘要
目的探讨血清胃促生长素(ghrelin)、脂联素在2型糖尿病肾病(DN)发生、发展中的作用。方法选择2型糖尿病(T2DM)患者90例,根据尿微量清蛋白排泄率(UAER)分为单纯糖尿病组30例、早期DN组30例、临床DN组30例,同时选取30例健康体检者作为正常对照组。测定所有受试者血清胃促生长素、脂联素水平,并分析其与UAER等指标的关系。结果 (1)单纯糖尿病组患者血清胃促生长素、脂联素水平均显著低于正常对照组(P<0.05),而早期DN组、临床DN组患者血清胃促生长素水平均显著高于单纯糖尿病组(P<0.01),临床DN组患者血清胃促生长素又显著高于正常对照组(P<0.05)。血清脂联素水平在单纯糖尿病组、早期DN组及临床DN组中随病情进展逐渐升高(P<0.05)。(2)在DN阶段,血清胃促生长素、脂联素水平均与体质指数(BMI)、空腹血糖、UAER、血肌酐水平相关。(3)逐步回归分析显示,糖尿病血清胃促生长素、脂联素受UAER、BMI的影响较大。结论胃促生长素、脂联素与DN发生、发展有关,检测其血清水平可能对早期诊断和评估DN有作用。胃促生长素、脂联素有望成为治疗DN的新靶点。
Objective To investigate the impact of ghrelin and adiponectin on the pathogenesis and progress type 2 diabetic nephropathy（DN）.Methods Ninety cases of type 2 diabetic mellitus patients were enrolled in this study and divided into 3 groups（30 cases each）,simple diabetes mellitus（SDM）,early diabetic nephropathy（EDN）,and clinical diabetic nephropathy（CDN）,according to the levels of urinary albumin excretion（UAER）.Then 30 healthy persons were enrolled as normal control.Levels of serum ghrelin and adiponectin in all subjects were measured,with their relationships with UAER analyzed.Results Serum levels of ghrelin and adiponectin were higher in the normal controls than in the SDM group（P0.05）,higher in the EDN group and the CDN group than in the SDM group（P0.01）,and higher in the CDN group than in the normal controls（P0.05）.Serum levels of adiponectin increased with the development of nephropaty in DN patients（P0.05）.Serum levels of ghrelin and adiponectin were correlated with levels of BMI,FBG,UAER and SCr in DN.Stepwise regression analyses showed that UAER and BMI had more impact on serum ghrelin and adiponectin levels.Conclusion Ghrelin and adiponectin may play important roles in the occurrence of the diabetic mellitus nephropathy.Levels of serum ghrelin and adiponectin may help with the early diagnosis and evaluation of DN.Ghrelin and adiponectin may serve as new targets for treatment of DN.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第21期2392-2395,共4页
Chinese General Practice
基金
广西医药卫生基金项目(Z2009065)
