摘要
目的探讨血清中P53基因的表达产物P53蛋白和抗P53蛋白抗体的检测对肺癌患者诊断的应用价值。方法应用Westernblot方法．对28例肺癌患者和18例对照的血清中的P53蛋白和抗P53蛋白抗体进行检测。结果分别在7.14％（2／28）和14.29％（4／28）的肺癌患者的血清中检测到P53蛋白和抗P53蛋白抗体，而良性肺疾病和健康对照组血清中求检测到这两种蛋白抗体。结论检测患者血清中的P53蛋白和抗P53蛋白抗体对肺癌患者具有一定的诊断价值。
To study the value of detecting P53 proteins and anti-P53 protein anti bodies; Methods we detected P53 proteins and anti P53 antibodies in sera of lung cancer patients and control subjects by western blot technique; ResuIts 7. 14% (2/28) and 14. 29 % (4/28) of the lung cancer patients sera were detected to have P53 proteins and anti-P53 antibodies respectively. No P53 protein and anti-P53 antibody was detected in the sera of controls;Conclusion The study suggested that detecting P53 proteins and anti-P53 antlbodies is valuable to the diagnosis of lung cancer.
出处
《中国肿瘤临床与康复》
1999年第6期22-22,21,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
