摘要
目的:探讨血管内皮生长因子C(VEGF-C)和环氧合酶-2(COX-2)的表达在胃癌的发生、发展及预后的临床意义。方法:采用S-P免疫组织化学方法,检测VEGF-C和COX-2在胃镜活检的正常胃黏膜(n=17)、浅表性胃炎(n=19)、萎缩性胃炎/肠化生(n=22)、胃黏膜不典型性增生(n=23)和胃癌患者1期(n=18),2期(n=24),3期(n=22),4期(n=18)的胃组织。结果:胃癌组织中的VEGF-C和COX-2的表达阳性率明显高于非胃癌组织,正常胃黏膜、浅表性胃炎、萎缩性胃炎/肠化生、胃黏膜不典型性增生至胃癌逐级之间的差异有统计学意义(P<0.05);在3及4期胃癌中的表达阳性率明显高于1及2期(P<0.05);VEGF和COX-2的表达具有显著相关性(P<0.01)。结论:VEGF-C和COX-2的共同表达在胃癌的发生发展可能起重要作用,联合检测VEGF-C和COX-2对胃癌的早期诊断、临床防治及预后可能具有重要临床价值。
Objective： To cance in occurrence, development explore the expression of VEGF and prognosis of gastric cancer. C and COX 2 and their clinical Methods： Expressions of VEGF ignifi-C and COX-2 were determined by S-P immunohistochemical staining analysis in stomach tissue of normal gastric mucosa（n=17）,atrophic gastritis（n=19） ,superficial gastritis（and/or atrophic gastritis）（n=22）,gastric mucosa not typical hyperplasia（n=23） and gastric cancer Ⅰ period （n=lS）, gastric cancerⅡ period（n= 24,）gastric cancer Ⅲ period （n = 22） and gastric cancer IV period（n = 18）. Results： The positive rates of VEGF-C and COX-2 were significantly higher in gastric cancer tissue than in tissue without gastric cancer. There were significant ＇difference in expressions of VEGF-C and COX 2 among normal gastric mucosa,atrophic gastritis, superficial gastritis （ and/or atrophic gastritis）, atypical hyperplasia gastric mucosa and gastric cancer tissue （P〈0.05）. The positive rate was significantly higher in stage 3 and 4 than stage 1 and 2 （P〈0.01）. The expression of VEGF C was significantly correlated with expression of COX-2 （P〈 0.01）. Conclusions： Co-expression of VEGF-C and COX-2 may play an important role in the occurrence and development of gastric cancer. Combined detection of VEGF-C and COX-2 is valuable in early diagno sis, prevention, treatment and prognosis of gastric cancer
出处
《海南医学院学报》
CAS
2011年第8期1122-1125,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110290)~~
关键词
胃癌
环氧合酶-2
血管内皮生长因子-C
Gastric cancer
C yclooxygenase-2
Vascular endothelial growth factor C
