摘要
目的观察奥美拉唑、多潘立酮抗反流治疗对支气管哮喘合并胃食管反流病患者哮喘的疗效。方法本研究采用随机、对照、双盲的方法,将50例合并胃食管反流病的哮喘患者分为两组,治疗组在常规哮喘药物治疗的同时加服奥美拉唑和多潘立酮,对照组加服安慰剂。观察治疗前后患者症状、肺功能的变化。结果抗反流治疗后治疗组每天哮喘症状评分较对照组改善,差异有统计学意义(P<0.05);治疗组肺功能指标FEV1、PEF及PEF变异率较对照组改善,差异有统计学意义(P<0.05或P<0.001)。结论对合并胃食管反流病的哮喘患者进行抗反流治疗,可改善哮喘症状及肺功能。
Objective To evaluate the effect of antireflux treatment on asthmatic patients with gastroesophageal reflux disease（GERD）.Methods Fifty patients were divided into two groups according o the randomized,double-blind,placebo-controlled method.Omeprazole and domperidone were added to the routine asthma treatment in the treatment group while placebo was added in the control group.The change of asthma symptom score and pulmonary function were observed before and after the treatment.Results After treatment,the asthma symptom score was improved in the treatment group,the difference had statistical significance（P〈0.05）compared to the control group.Pulmonary function index FEV1,PEF and PEF variability were improved in the treatment group,the differences compared to the control group had statistical significance（P〈0.05 or P〈0.01）.Conclusion Antireflux treatment in asthmatics with GERD can improve asthma symptoms and pulmonary function of the patients.
出处
《当代医学》
2011年第21期149-150,共2页
Contemporary Medicine
