摘要
目的：观察气管切开早期高渗盐水雾化对排痰的影响。方法：以家兔气管切开为研究模型，将18只家兔随机分成3组：正常对照组、等渗盐水雾化组、高渗盐水雾化组。通过雾化过程心电及氧舍监测、痰液检测、黏膜-纤毛光镜，比较不同雾化方法在气管切开早期增加气道蛤药的安全性，促进痰液排出，抑制气道炎症的作用。结果：①气道安全性：高渗雾化B、C两组雾化结束时呼吸、心率均低于等渗盐水组，氧合情况均优于等渗盐水组；各指标差畀有辘计学意义．②痰泣黏稠度：高渗雾化B，C两组痰液黏稠度均低于等渗盐水组。③痰液活菌比例：高渗雾化B、C两蛆痰注活茸比例均低于等渗盐水组。④黏膜损伤病理检查：高渗雾化B、C两组黏膜损伤程度均低于等渗盐水组。结论；气管切开早期气遗处于黏膜高分泌、高水肿的高炎症状态，应用3%NaCL等渗当量的高渗溶液进行雾化，能减轻黏膜水肿，堆持氧合水平，促进痰液稀释和排出，并具有一定的抗炎作用．
To observe hypertonic saline aerosol effect on discharge sputum in the early tracheotomy. Methods： The tracheotomy rabbit model, 18 rabbits were randomly divided into 3 groups： normal control group, isotonic saline spray group, saline spray groups. ECG by the atomization process and oxygenation monitoring, sputum testing, mucosa -- dlia light microscope, comparing early tracheotomy atomized approach to increase airway administration of safety, promote mucus discharge, inhibition of airway inflammationeffect. Results 1 to secure the airway： hypertonic aerosol spray in each group at the end of breathing and heart rate were lower than the normal saline group, oxygenation is superior to normal saline group; There were significant differences of each index. 2, sputum viscosity： hypertonic aerosol sputum viscosity in each group were lower than the normal saline group. 3, the proportion of viable cells in sputum： sputum viable hypertonic aerosol proportion of each group were lower than normal saline group. 4, mucosal injury pathology： hypertonic aerosol mucosal injury in each group were lower than the normal saline group. Conclusions： Early tracheostomy in airway mucus hypersecretlon, edema of high inflammatory state high, the application equivalent of 3 % NaCL isotonic hypertonic solution to spray, can reduce mueosal edema, maintain oxygenation levels, and promote sputum dilution and discharge, and has some antl--inflammatory effect.
关键词
高渗盐水
气管切开
家兔
Hypertonic saline tracheotomy rabbits
