摘要
目的：通过分析接汞作业工人尿液的β2-MG，尿汞及cr检测结果，探讨β2-MG作为汞中毒肾脏早期损害的临床价值。方法：收集佛山有接汞作业工序的生产企业接汞作业和非接汞作业工人的尿液，检测尿液标本的B2-MG、汞及Cr，依据汞中毒诊断标准对工人分为汞中毒组及对照组，分析两组尿液的汞，β2-MG和Cr结果。结果：早期汞作业人群与对照人群相比，尿汞及尿肌酐无显著性差异（t=1．08，P〉0．05，），β-MG差异显著（t=5．7，P〈0．01）；半年追踪检测结果，尿汞值达（2．75±0．57）ug／mmolCr，尿肌酐检测值无超标，β2-MG差异显著增大（t=5．81，p〈0．01）；-年追踪检测结果，尿汞值为（3．16±0．82）ug／mmolCr。尿肌酐检测值（17．98±2．78）mmol／L，β2-MG差异极其显著（t=5．81，P〈0．01）。结论：结果表明β2-MG是对接触汞作业工人肾功能损害较为敏感的早期诊断指标，可作为早期预警的检测指标。
Objective： To evaluate significance of β2- MG for early warning of renal damage in mercury workers by analyzing urinary β2- MG, Hg and Cr in mercury wo Cr was （3.16±0.82）ug/mmolCr and （17.98±2.78） mmol/L respectively. The lever of β2- MG was extremely significant difference（t = 5.81 ,P〈0.01）rkers. Methods：The urine sample of mercury workers and no mercury exposure history workers in Foshan were collected, detection uri- nary β2- MG, Hg and Cr. The workers were divided into hydragyrism group and control group according to the standard of hydrargyrinsm. The result of urinary β2- MG, Hg and Cr in the two groups were analyzed. Result： The levers of urinary Hg and Cr in early mercury workers were no statistically signif- icant difference Compared with the control group（t= 1.08, P〈0.05）, but the lever of β2- MG was significant difference. The half--year pursue results show the lever of urinary Hg was（2.75±0.57）ug/mmolCr, the lever of urinary Cr was normal, the lever of β2- MG was significantly higher. The one-- year pursue results show the lever of urinary Hg and Cr was （3.16±0.82）ug/mmolCr and （17.98±2.78） mmol/L respectively. The lever of β2- MG was extremely significant diifference（t=5.81 ,P〈0.01）. Conclusion：The lever of urinary β2- MG can be used as a sensitive indicator for detecting early renal damage caused by mercury.
