摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液(EBC)中炎症因子检测的临床意义。方法选择经多导睡眠监测确诊的OSAHS患者50例和正常对照30例,采用酶联免疫技术分别检测EBC和血清中白三烯B4、肿瘤坏死因子-α的浓度,30例OSAHS患者经治疗三月后再次检测。结果①OSAHS组EBC和血清中LTB4及TNF-α水平均明显高于对照组,P均<0.05。②OSAHS患者EBC中LTB4和TNF-α水平与AHI正相关;与睡眠中LSpO2、MSpO2负相关。③OSAHS患者治疗后EBC中LTB4和TNF-α水平较治疗前下降,差异有统计学意义,P<0.01。结论 EBC中炎症因子检测对判断OSAHS患者病情严重程度和治疗效果具重要意义。
Objective To investigate the clinical significance of testing inflammation factor in exhaled breath condensate（EBC） of patients with OSAHS.Methods 50 patients with OSAHS diagnosed by PSG（30 patients with treatment for about 3 months） and 30 age matched controls were enrolled in the study.Leukotriene B4 and tumor necrosis factor α levels were measured by enzyme linked immunosorbent assay.Results ①The levels of LTB and TNF-α in EBC and serum with OSAHS were significantly higher than that in the control group（all P0.05） ②LTB4 and TNF-α levels in EBC were positively correlated with AHI and negatively correlated with LSpO2 and MSpO2.③During the period of three months＇ treatment there was such a further significant decrease in LTB4 and TNF-α in EBC in 30 patients with OSAHS.Conclusions There was important clinical significance of detection of inflammation factors in EBC in monitoring the severity and treatment of OSAHS.
出处
《临床肺科杂志》
2011年第8期1170-1172,共3页
Journal of Clinical Pulmonary Medicine
