摘要
建立一种同时快速定量分析阿司匹林合成体系中阿司匹林和水杨酸的方法。通过均匀设计构造样本并采集其紫外光谱,结合偏最小二乘法(PLS)建立同时测定混合体系中阿司匹林和水杨酸的校正模型,阿司匹林和水杨酸模型的校正均方根误差分别为1.708μg/mL和0.435μg/mL。该模型用于预测氨基磺酸催化合成过程中阿司匹林和水杨酸含量,二组分回收率在93.48%—108.37%之间,相对标准偏差(RSD)分别为3.45%和4.80%。结果表明,紫外光谱法结合PLS模型实现氨基磺酸催化合成阿司匹林过程的实时监测是可行的。
A method for simultaneous and quantitative analysis of aspirin and salicylic acid in synthesis systems of aspirin was developed.Uniform design was applied in synthesis systems of aspirin,and its ultraviolet spectroscopy was collected,then the calibration models for simultaneous determination of aspirin and salicylic acid were established by partial least squares（PLS）.The root mean square errors calibration for models of aspirin and salicylic acid were 1.708μg/mL and 0.435μg/mL.The model was applied to predict the concentration of aspirin and salicylic acid in the process of synthesis of aspirin with sulfamic acid as catalysis,while the recoveries ranged from 93.48% to 108.37%,and the relative standard deviation（RSD） were 3.45% and 4.80%.There was feasible to monitor the synthesis process of aspirin over catalysis of sulfamic acid in real-time by ultraviolet spectroscopy combined with PLS models.
出处
《光谱实验室》
CAS
CSCD
北大核心
2011年第4期1911-1915,共5页
Chinese Journal of Spectroscopy Laboratory
基金
广西自然科学基金资助项目(桂科自0832064)
广西教育厅桂教科研资助项目(200708MS067)
关键词
阿司匹林
水杨酸
紫外光谱法
偏最小二乘法
Aspirin
Salicylic Acid
Ultraviolet Spectroscopy
Partial Least Squares
