摘要
建立高效液相色谱法测定咖酚伪麻片中盐酸伪麻黄碱含量的方法。色谱柱为C18(150mm×4.6mm×5μm),流动相为0.05mol/L磷酸二氢钠-甲醇(75∶25),流速为1mL/min,检测波长为210nm。盐酸伪麻黄碱在0.2155—1.0776μg/g范围内线性良好,r=0.9999;盐酸伪麻黄碱的平均收率为100.92%,RSD值为0.41%(n=5)。此法操作简单,准确性好,可用于咖酚伪麻片中盐酸伪麻黄碱的含量测定。
The method for the determination of the content of the pseudoephedrine hydrochloride in the paracetamol,pseudoephedrine hydrochloricle and caffeine tablets was established by high performance liquid chromatography（HPLC）.The chromatograph column was C18（150mm×4.6mm×5μm）,and the mobile phase was 0.05mol / L sodium dihydrogen phosphate-methanol（75∶25） with flow rate of 1mL/min at detection wavelength of 210nm.There was a good linearity for pseudoephedrine hydrochloride in the range of 0.2155—1.0776μg/g with r=0.9999.The average recovery was 100.92% with RSD of 0.41%（n=5）.The method is simple,and has good accuracy,and can be applied to determination of pseudoephedrine hydrochloride in the paracetamol,pseudoephedrine hydrochloricle and caffeine tablets.
出处
《光谱实验室》
CAS
CSCD
北大核心
2011年第4期2004-2007,共4页
Chinese Journal of Spectroscopy Laboratory
关键词
咖酚伪麻片
盐酸伪麻黄碱
高效液相色谱法
Paracetamol
Pseudoephedrine Hydrochloride and Caffeine Tablets
Pseudoephedrine Hydrochloride
HPLC
