摘要
为探讨姜黄素的降血脂和抗动脉粥样硬化作用是否通过影响低密度脂蛋白和脂蛋白（ａ） 的代谢来实现的，用姜黄素经剌猬腋下静脉注入，２ ｍｉｎ 后注射１２５ Ｉ－ 低密度脂蛋白、１２５ Ｉ－ 脂蛋白（ａ） 、１２５ Ｉ－ 去唾液酸低密度脂蛋白或１２５ Ｉ－ 去唾液酸脂蛋白（ａ），１ 小时后处死动物，测定血、肝、肾、脾、胆汁和肾上腺中的放射性含量。实验发现：姜黄素使低密度脂蛋白进入肝脏和肾上腺增多，胆囊中的含量增加，而进入脾脏的含量降低；姜黄素对脂蛋白（ａ）的作用与对低密度脂蛋白的作用相似，但不如对低密度脂蛋白的作用明显。姜黄素对去唾液酸低密度脂蛋白代谢有部分抑制作用，但对去唾液酸脂蛋白（ａ） 的作用不十分明显。实验认为姜黄素可能通过促进肝和肾上腺对低密度脂蛋白和脂蛋白（ａ） 的代谢，增加胆囊对低密度脂蛋白排泄，抑制脾对低密度脂蛋白的摄取，使血中低密度脂蛋白和脂蛋白（ａ）的含量降低，从而起到降血脂和抗动脉粥样硬化作用。
Aim To study the effects of cucurmin on the metabolism of low density lipoprotein and lipoprotein (a). Methods Cucurmin was injected into the body of hedgehogs via the armpit vein 2 minutes before the 125 iodine low density lipoprotein ( 125 ?I-LDL), 125 iodine lipoprotein(a) ( 125 I-Lp(a)), 125 iodine desialylated low density lipoprotein ( 125 I-ds-LDL) or 125 iodine desialylated lipoprotein(a) ( 125 I-ds Lp(a)) were injected. The animals were put to death in 1 hour. The radioactivity of 125 I-LDL, 125 I-Lp(a), 125 I-ds-LDL and 125 I-dsLp(a) in the blood, liver, kidney, spleen, gall and adrenal were measured . Results Experiments showed that the absorption of LDL in liver, adrenal and gall increased 228.1%, 86.7% and 70.3% respectively, but decreased 54.4% in spleen and 25.8% in blood. The effects of cucurmin on Lp(a) were similar to that on LDL. The absorption of Lp(a) in liver and adrenal increased 34.7% and 43.1% respectively, but decreased 34.8% in kidney and 19.2% in blood. The absorption of ds-LDL in liver, kidney, adrenal and blood decreased 15.1%, 43.6%, 68.2% and 31.8% respectively, but increased 31.7% in gall. Cucurmin has slightly effects on the metabolism of ds Lp(a). Conclusion Experiments proved that cucurmin may promote the metabolism of LDL and Lp(a) in liver and adrenal, increase excretion of LDL by gall and inhibit the absorption of LDL in spleen. It make the concentration of LDL and Lp(a) in blood decrease and achieve the effects of lowering lipids and antiatherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
1999年第4期339-341,共3页
Chinese Journal of Arteriosclerosis
关键词
低密度脂蛋白
脂蛋白
病黄素
动脉粥样硬化
Lipoproteins, LDL
Lipoprotein (a)
Metabolism
Desialylated Low Density Lipoprotein
Desialylated Lipoprotein(a)
Cucurmin
Atherosclerosis
