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PD-1/PD-L信号通路:研究现况与展望 被引量:4

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摘要 程序性死亡受体-1(programmed cell death-1,PD-1)及其配体(PD-L1,PD-L2)是CD28/B7超家族成员,广泛表达于各种组织。PD-1/PD-L共刺激信号视机体的炎症程度、免疫状态和遗传背景不同而激活或抑制,主要参与T细胞的中枢及外周免疫耐受。与其他CD28超家族成员相比,PD-1信号通路发挥着更广泛和复杂的免疫调节作用,与自身免疫病、肿瘤、慢性感染及炎症密切相关。因此,能否通过PD-1/PD-L信号通路来调节自身免疫状态,从而治疗相关疾病,成为人们研究的热点。本文将对近年来的研究做一总结。
出处 《现代免疫学》 CAS CSCD 北大核心 2011年第4期335-339,共5页 Current Immunology
基金 广东省自然科学基金资助项目(10151051501000038)
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参考文献24

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二级参考文献28

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