摘要
目的：了解Ｆａｓ 抗原及ｂｃｌ２ 蛋白在甲状腺肿瘤组织中表达的意义。方法：用流式细胞技术对１４ 例乳头状甲状腺癌，１６例甲状腺腺瘤及３２ 例结节性甲状腺肿组织中Ｆａｓ 抗原和ｂｃｌ２ 蛋白的表达进行检测。结果：上述３ 组织中均测到Ｆａｓ 抗原和ｂｃｌ２ 蛋白。３ 种组织中Ｆａｓ 抗原和ｂｃｌ２ 蛋白表达没有统计学差异（Ｆ＝２．７８，Ｐ＞０．０５；Ｆ＝２．５６，Ｐ＞０．０５）。乳头状甲状腺癌组织Ｆａｓ 抗原表达与ｂｃｌ２ 蛋白表达有明显相关性（ｒ＝０．６４６，Ｐ＜０．０５），其他两种组织中Ｆａｓ 抗原与ｂｃｌ２ 表达均无相关性（ Ｐ＞０－０５）。结论：上述３ 种组织中均有Ｆａｓ 抗原和ｂｃｌ２ 蛋白的表达，均参与了甲状腺肿瘤组织中细胞凋亡的调节。细胞凋亡异常与乳头状甲状腺癌的发生有密切关系。
Objective:To investigate the significance of expression of Fas antigen and bcl 2 protein in thyroid tumors.Methods:The expression of Fas antigen and bcl 2 protein 14 patients with papillary adenocarcinoma,16 patients with thyroid adenoma and 32 patients with nodular goiter were determined with flow cytometry.Results:Fas antigen and bcl 2 protein were phenoty pically expressed in various thyroid gland tissues.The expression of Fas antigen or bcl 2 protein had no statistic difference among various thyroid gland tissues(F=2.78,P>0.05;F=2.56,P>0.05).There was significant correlation between Fas antigen expression and bcl 2 protein expression in papillary adenocarcinoma(r=0.646,P<0.05),without statistic correlation in thyroid adenoma or nodular goiter(r= 0.339,P>0.05;r= 0.165,P>0.05).Conclusions:These results suggest that apoptotic process takes place in benign and malignant lesions of thyroid gland.Fas mediated apoptosis play an important role in the pathogenesis of papillary adenocarcinoma.
出处
《中国优生与遗传杂志》
1999年第6期19-20,共2页
Chinese Journal of Birth Health & Heredity
