摘要
目的:检测p53和Gadd45α蛋白在皮肤鳞状细胞癌和基底细胞癌组织中的表达。方法:应用免疫组化法对30例皮肤鳞状细胞癌和25例基底细胞癌组织中的p53和Gadd45α蛋白表达进行检测。结果:p53蛋白在皮肤鳞状细胞癌和基底细胞癌组织中的表达阳性率分别为56.67%、48%,与正常皮肤组织比较差异均有显著性(P=0.006;0.025);Gadd45α在皮肤鳞状细胞癌和基底细胞癌中表达分别为43.33%、52%,均高于正常皮肤组织的表达(P=0.031;0.010)。高分化皮肤鳞状细胞癌组阳性表达率为75%,高于中低分化组的22.22%(P=0.008)。结论:皮肤鳞状细胞癌和基底细胞癌组织中p53、Gadd45α异常表达可能参与了发病过程。
Objective： To detect the expression of 1353 and Gadd45α proteins in cutaneous squamous cell carcinoma （SCC） and basal cell carcinoma （BCC）. Methods： The expression of p53 and Gadd45α proteins were detected with immunohistochemistry in 30 patients with SCC and 25 patients with BCC. Results： The positivity rate in the expression of 1353 protein was 56.67 % （17/30） and 44% （11/25） in SCC and BCC respectively, which was significantly higher than normal skin （ P =0. 006 and P = 0. 025）. The posifivity rate in the expression of Gadd45α protein was 43.33% （13/30） and 52% （13/25） in SCC and BCC which was significantly higher than that in normal skin （ P = 0.031 and P = 0.010）. The expression in welldifferentiated patients was higher than that in moderate/low differentiated patients （ P = 0.008）. Conclusion： The abnormal expression of p53 and Gadd45α may play a role in the malignant process of SCC and BCC.
出处
《中国麻风皮肤病杂志》
2011年第7期455-457,共3页
China Journal of Leprosy and Skin Diseases
基金
CDA-宝洁基金
