摘要
血管平滑肌和内皮细胞的Ｃａ２＋内流机制不同，前者是兴奋性细胞，Ｃａ２＋内流通过电压依赖性（ＶＤＣ）和非电压依赖性Ｃａ２＋通道；后者是非兴奋性细胞，Ｃａ２＋内流主要通过非ＶＤＣ途径。Ｃｌ－通道参与了这两种细胞的Ｃａ２＋调控，平滑肌细胞Ｃｌ－通道开放导致细胞膜去极化，促进ＶＤＣ开放，Ｃａ２＋内流增加；而内皮细胞Ｃｌ－通道开放导致细胞膜超极化，使Ｃａ２＋进入细胞内的电化学趋势增加，胞外Ｃａ２＋经非ＶＤＣ途径内流增加。目前对血管平滑肌和内皮细胞Ｃｌ－通道的分型、特性和功能还不清楚。
Ca 2+ influx mechanisms are different in vascular smooth muscle cells (VSMC) and endothelial cells (VEC). VSMC are excitable cells, in which voltage dependent Ca 2+ channels (VDC) generally accomplish Ca 2+ influx, and Ca 2+ release activated Ca 2+ influx(CRAC) might also be important for the regulation of smooth mucle tone. While in non excitable cells like VEC, in which VDC is not expressed, CRAC may be the predominant pathway for Ca 2+ influx. Cl - channels exist in both VSMC and VEC. Activation of their Cl - channels results in membrane depolarization or hyperpolarization respectively. The depolarization of the VSMC membrane increases the number of open VDC, and induces Ca 2+ entry. While the hyperpolarization of the VEC membrane allows Ca 2+ removal to lower intracellular Ca 2+ , and increases Ca 2+ entry, too.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第3期212-215,共4页
Chinese Pharmacological Bulletin
关键词
血管平滑肌细胞
血管内皮细胞
钙离子通道
vascular smooth muscle cell
vascular endothelial cell
Ca 2+ channel
Cl - channel
