摘要
目的研究血清血管内皮生长因子（VEGF）和基质金属蛋白酶9（MMP-9）含量的动态变化在脑梗死治疗和预后判断中的意义。方法选取123例急性脑梗死患者为观察组，80例健康体检者为对照组。分别于发病后1、3、5、7、14d时对急性脑梗死患者进行血清VEGF和MMP-9含量检测，并研究其与患者梗死面积和预后的相关性。结果发病后1、3、5、7、14d时血清VEGF和MMP．9的含量呈现一种先升后降的状态，但观察组均显著高于对照组（P〈0．01）。预后不良患者在发病后各时段血清VEGF[（369．3±108．7），（476．2±118．4），（551．5±144．5），（661．7±164．6），（437．6±123．9）n异／L]和MMP．9[（333．8士101．4），（459．7±119．9），（370．3±119．5），（320．5±129．1），（255．4±101．6）ng／L]含量均明显高于预后良好者（均P〈0．01）。结论急性脑梗死患者血清中VEGF和MMPO含量均呈现一种动态的变化状态，且与梗死面积及预后呈现一种较为紧密的关系。
Objective To study the significance on dynamic changes of serum vascular endothelial growth factor（VEGF） and matrix metalloproteinase 9 （MMP-9） in patients with acute cerebral infarction. Methods 123 patients with acute cerebral infarction were selected as research object, and they were the observation group, and 80 healthy peoples at the same time were selected as control group. Then the serum VEGF and MMP-9 in patients with acute cerebral infarction after pathogenesis at first, third, fifth, seventh and fourteenth day were detected, and the correction between the levels and infarct size, prognosis were studied. Results The serum VEGF and MMP-9 of observation group compared with those of control group, the change showed increased first and decreased afterwards, but the levels were all higher than those of control group（ P 〈 0.01 ）. There were correction between the levels and infarct size ,prognosis. The serum VEGF [ （ 369.3 ± 108.7,476.2 ± 118.4,55 1. 5 ± 144.5,661.7 ± 164.6,437.6± 123.9） ng/L ] and MMP-9 [ （333.8± 101.4,459.7 ± 119.9,370.3 ±119.5,320.5 ±129.1,255.4 ±101.6 ） ng/L ] in poor prognosis patients after pathogenesis at first, third, fifth, seventh and fourteenth day were all higher than those of good prognosis patients （P 〈 0.01 ）. Conclusion The serum VEGF and MMP-9 in patients with acute cerebral infarction showed dynamic change, and there was close relationship between the levels and infarct size.
出处
《中国基层医药》
CAS
2011年第13期1735-1736,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑梗死
血管内皮生长因子A
基质金属蛋白酶9
Brain infarction
Vascular endothelial growth factor A
Matrix metalloproteinase 9
