摘要
背景:不同生物材料制备的复合软骨支架其修复软骨缺损也各具特点。目的:探讨不同生物材料制备复合支架的组织工程学特性及其修复关节软骨缺损的性能评价。方法:以"软骨组织工程,生物材料,工程软骨,复合支架"为中文关键词,以"tissue enginneering,articular cartilage,scaffold material"为英文关键词,采用计算机检索中国期刊全文数据库、PubMed数据库(1993-01/2010-11)相关文章。纳入复合支架材料-细胞复合物修复关节软骨损伤等相关的文章,排除重复研究或Meta分析类文章。结果与结论:复合支架是当前软骨组织工程中应用较多的支架,它是将具有互补特征的生物相容性可降解支架,按一定比例和方式组合,设计出结构与性能优化的复合支架。较单一支架材料具有更好的生物相容性和一定强度的韧性,较好的孔隙和机械强度。复合支架的制备不仅包括同一类生物材料的复合,还包括不同类别生物材料之间的交叉复合。可分为纯天然支架材料、纯人工支架材料以及天然与人工支架材料的复合等3类。复合支架使生物材料具有互补特性,一定程度上满足了理想生物材料支架应具的综合特点,但目前很多研究仍处于实验阶段,还有一些问题有待于解决,如不同材料的复合比例、复合工艺等。
BACKGROUND：Composite scaffolds prepared by different biomaterials have their own characteristics in the repair of cartilage defects.OBJECTIVE：To investigate the tissue engineering characteristics and effect evaluation of composite scaffolds prepared by different biomaterials for repairing articular cartilage defects.METHODS：The key words were ＂cartilage tissue engineering,biomaterials,engineered cartilage,composite scaffold＂ in Chinese and ＂tissue engineering,articular cartilage,scaffold material＂ in English.A computer based search of CNKI and PubMed databases was performed for relevant articles about composite scaffolds with cells for articular cartilage defects published from 1993-01 to 2010-11.Repetitive articles or Meta analysis were excluded.RESULTS AND CONCLUSION：Composite scaffolds are commonly used in cartilage tissue engineering,which are degradable scaffolds with better biocompatibility,toughness,porosity and mechanical strength than single scaffolds.Composite scaffolds are prepared not only by the same type of biomaterials but also by different kinds of biomaterials,which can be divided into natural scaffolds,artificial scaffolds,natural and artificial scaffolds.Complementary properties of biomaterials based on composite scaffolds meet the requirement of the ideal biomaterial scaffold to some extent.Nowadays,there are still some problems to be solved,such as compound ratio of different biomaterials and composite process.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第25期4723-4725,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
