摘要
背景:我国脂肪肝发病率呈逐年增长趋势且主要与肥胖症而非酒精滥用有关,寻找测量简便的非酒精性脂肪性肝病(NAFLD)预测指标具有重要意义。目的:探讨反映人体脂肪蓄积程度的脂肪/非脂成分比值(FFR)与非酒精性脂肪肝的关系。方法:以1025例上海市公务员为研究对象行横断面研究,调查和检测内容包括人口统计学资料、体质指数(BMI)、腰围(WC)、有无脂肪肝、人体成分分析、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)等,以单因素和多因素非条件logistic回归分析FFR与非酒精性脂肪肝的关系。结果:脂肪肝组与非脂肪肝组FFR的中位数和四分位数间距分别为0.39(0.33,0.45)和0.34(0.28,0.40),组间差异有统计学意义(P<0.001)。根据FFR的四分位数将研究对象按FFR由低至高分为四组,以FFR最低组为参照,调整性别、年龄、BMI、WC、FPG、TG、HDL-C因素后,各组发生脂肪肝的OR(95%CI)分别为1.37(0.82,2.28)、1.80(1.06,3.07)、2.59(1.44,4.67),脂肪肝发生风险随FFR的增高呈上升趋势(trend P<0.001)。结论:FFR增高与非酒精性脂肪肝相关,两者间存在剂量-反应关系。
Fatty liver is highly prevalent in China in recent years and is more often linked to obesity than to alcoholism. It is of great importance to find a simple predictor for nonalcoholic fatty liver disease （NAFLD）. Aims： To investigate the association between body fat mass to fat-free mass ratio （FFR）, an index reflecting the accumulation of body fat, and nonalcoholic fatty liver. Methods： A cross-sectional study was carried out in 1025 civil servants in Shanghai. Items including demographic data, body mass index （BMI）, waist circumference （WC）, existence of fatty liver, body composition, and levels of fasting plasma glucose （FPG）, triacylglycerol （TG） and high density lipoprotein cholesterol （HDL-C） were surveyed. Association between FFR and nonalcoholic fatty liver was analyzed by using univariate and multivariate unconditional logistic models. Results： Medians （inter-quartile range） of FFR were 0.39 （0.33, 0.45） and 0,34 （0.28, 0.40） in subjects with and without fatty liver, respectively, with a significant difference between the two groups （P〈 0.001）. Adjusting for all covariates including gender, age, BMI, WC, FPG, TG and HDL-C and with the lowest quartile as a reference, the ORs （95% CI） of fatty liver in the 2nd, 3rd and 4th quartiles of FFR were 1.37 （0.82, 2.28）, 1.80 （1.06, 3.07） and 2.59 （1.44, 4.67）, respectively. The risk of fatty liver increased with the increase in FFR （trend P〈0.001）. Conclusions： Elevated FFR is associated with nonalcoholic fatty liver. There is a dose-response trend between FFR and risk of nonalcoholic fatty liver.
出处
《胃肠病学》
2011年第6期341-344,共4页
Chinese Journal of Gastroenterology
