期刊文献+

我院2007-2010年糖肽类抗菌药的使用与革兰阳性球菌的耐药性分析 被引量:8

Utilization of Glycopeptides Antibiotics and Bacterial Resistance of Gram Positive Coccus in Our Hospital from 2007 to 2010
原文传递
导出
摘要 目的:了解我院糖肽类抗菌药的应用现状和革兰阳性球菌分离率及耐药情况,为临床合理应用抗菌药提供依据。方法:对我院2007-2010年住院患者糖肽类抗菌药的用药频度(DDDs)、销售金额等数据进行统计、分析,并将各科室送检标本检出的革兰阳性球菌分布及药敏试验结果进行汇总。结果:4年来我院住院患者糖肽类抗菌药的DDDs持续增加。4年中分离率在前6位的革兰阳性球菌分别为金黄色葡萄球菌、凝固酶阴性葡萄球菌、肺炎链球菌、粪肠球菌、屎肠球菌、β溶血链球菌;其中金黄色葡萄球菌分离率始终保持在第1位,占所有分离菌的11.0%~14.4%,未发现对万古霉素、利奈唑胺不敏感的葡萄球菌;屎肠球菌的耐药性高于粪肠球菌;耐万古霉素肠球菌(VRE)分离率呈上升趋势。结论:应加强对糖肽类抗菌药合理应用管理,以延缓耐万古霉素葡萄球菌的产生。 OBJECTIVE:To probe into the utilization of glycopeptides antibiotics,and to understand isolation rate and drug resistance of gram positive coccus in our hospital in order to provide reference for clinical rational use of antibiotics.METHODS:The DDDs and consumption sum of glycopeptides antibiotics in the inpatients were analyzed in our hospital from 2007 to 2010.Bacteria distribution of specimens approved by various departments and results of drug susceptibility test were summarized.RESULTS:The DDDs of glycopeptides antibiotics had increased year by year.Top 6 gram positive coccus in the list of isolation rate in 4 years were Staphylococcus aureus,Coagulase-nagetive Staphylococcus,Streptococcus pneumonia,Enterococcus faecium,Enterococcus faecalis,Streptococcus beta-haem.Staphylococcus aureus took up the first place in the list of isolation rate,the detection rate to gram positive coccus was from 11.0% to 14.4%.Vancomycin and linezolid resistance strains did not appear.The resistance rate of Enterococcus faecium was higher than that of Enterococcus faecalis.The isolation rate of Enterococcus resistance to vancomycin had an increasing tendency.CONCLUSION:We should enhance the management of glycopeptides antibiotics application in order to postpone the emergence of vancomycin-resistant Staphylococcus aureus.
出处 《中国药房》 CAS CSCD 北大核心 2011年第30期2833-2836,共4页 China Pharmacy
关键词 糖肽类抗菌药 用药频度 革兰阳性球菌 分离率 耐药性 Glycopeptides antibiotics DDDs Gram positive coccus Isolation rate Drug resistance
  • 相关文献

参考文献6

  • 1Isenberg HD.Clinical Microbiology Procedures Handbook (2nd Ed) [M]. ASM press Washington DC, USA, 2004, Aerobic Bacteriology, 3.0.1-4.0.1.
  • 2Murray PR. Manual of Clinical Microbiology (8nd Ed) [M]. ASM press Washington DC, USA, 2003:1 037.
  • 3Clinical and Laboratory Standards Institute (CLSI)/NCCLS. Performance Standards for Antimicrobial Susceptibility testing Standards: Fifteenth Informational Supplement[S]. 2005, M100.
  • 4朱德妹,胡付品,汪复,蒋晓飞,俞云松,杨青,孙自镛,简翠,王传清,王爱敏,张泓,李万华,徐英春,孙宏莉,倪语星,孙景勇,徐元宏,沈继录,胡云建,艾效曼,单斌,杜艳,魏莲花,吴玲,苏丹虹,卓超,贾蓓,黄文祥,张朝霞,季萍.2009年中国CHINET葡萄球菌属细菌耐药性监测[J].中国感染与化疗杂志,2010,10(6):414-420. 被引量:60
  • 5赖善城,林素珍,毛平.我院2006~2008年粪肠球菌和屎肠球菌耐药性分析[J].中国药房,2010,21(30):2836-2837. 被引量:9
  • 6杨青,俞云松,倪语星,孙景勇,徐英春,孙宏莉,孙自镛,简翠,汪复,朱德妹,胡付品,蒋晓飞,王传清,王爱敏,卓超,苏丹虹,胡云建,艾效曼,黄文祥,贾蓓,张朝霞,季萍,张泓,李万华,魏莲花,吴玲,徐元宏,沈继录,单斌,杜艳.2009年中国CHINET肠球菌属细菌耐药性监测[J].中国感染与化疗杂志,2010,10(6):421-425. 被引量:61

二级参考文献11

共引文献120

同被引文献67

  • 1刘忠,刘立,陈冠容.武汉25所医院2004~2005年头孢菌素应用分析[J].药物流行病学杂志,2006,15(5):289-291. 被引量:16
  • 2何慧丽,鲁燕侠,严莲珍.喹诺酮类抗菌药物的临床应用[J].中华医院感染学杂志,2007,17(6):725-725. 被引量:26
  • 3陈新谦,金有豫,汤光.新编药物学[M].第17版.北京:人民卫生出版社,2011:32-33.
  • 4卫生部抗生素临床药理基地.抗菌药物临床研究指导原则.中国临床药理学杂志,1987,2:189-191.
  • 5Livermore DM. Antibiotic resistance in staphylococci[J]. Int J Antimicrob Agents, 2000,16(Suppl 1 ) : 3.
  • 6Reynolds PE. Structure, biochemistry and mechanism of action of glycopeptide antibiotics[J]. Eur J Clin Microbiol Infect Dis, 1989,8 ( 11 ) : 943.
  • 7Kanellakopoulou K, Papadopoulos A, Varvaroussis D, et al. Efficacy of teicoplanin for the prevention of surgical site infections after total hip or knee arthroplasty: a prospec- tive, open-label study[J]. Int J Antimierob Agents, 2009, 33(5):437.
  • 8中华人民共和国卫生部.药品不良反应报告和监测管理办法[S].卫生部令第81号,2011-05-04.
  • 9Manfredi R, Sabbatani S. Novel pharmaceutical molecules against emerging resistant gram-positive cocci[J]. Braz J Infect Dis , 2010 ,14 (1) :96.
  • 10Boucher HW, Talbot GH, Bradley JS, et al.Bad bugs, no drugs:no ESKAPE! An update from the Infectious Diseas- es Society of America[J].Clin Infect Dis, 2009,48 ( 1 ) : 1.

引证文献8

二级引证文献38

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部