摘要
为了优化β-环糊精微球的制备工艺,采用U13*(134)均匀设计对合成工艺优化,得出最佳合成工艺为反应温度80℃,反应时间4 h,交联剂的用量8 g,搅拌速度1000 r/min。影响微球粒径的因素:搅拌速度>反应温度。影响产量的因素:交联剂的用量>反应时间。最佳合成工艺下的微球表面圆整,具有较好的热稳定性。
The preparation of β-cyclodextrin microspheres was optimized by using U13＊（134）uniform design.The result showed that the optimμm reaction temperature was 80 ℃,reaction time was 4 h,the amount of crosslinker was 8 g and stirring speed was 1000 r/min.The factors affecting microsphere size were stirring speed,and reaction temperature.The factors affecting yield were crosslinking agent,and reaction time.The surface of those β-CD microspheres under optimal conditions was smooth and had good thermal stability.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2011年第8期1785-1788,共4页
Chemical Industry and Engineering Progress
基金
国家自然科学基金(50573046)
陕西科技大学研究生创新基金项目
关键词
β-环糊精微球
均匀设计
热稳定性
β-cyclodextrin microspheres
uniform design
thermal stability
