摘要
目的:探讨氯吡格雷治疗急性心肌梗死(AMI)的有效性和安全性。方法:选择符合溶栓治疗适应证、无溶栓治疗禁忌证发病12 h以内的急性心肌梗死患者107例,将其分为观察组和对照组。对照组44例,给予肠溶阿司匹林片口服,尿激酶静脉溶栓治疗,溶栓12 h后皮下注射低分子肝素钙;观察组63例,在对照组治疗基础上加用氯吡格雷负荷量300 mg,以后75 mg/d。对两组间血管再通率、冠状动脉内血栓形成率和治疗后心肌梗死再发率、出血率、病死率及梗死后心绞痛发生率等进行比较分析。结果:患者经治疗后心绞痛发生率、再发心肌梗死率、血管再通率、冠脉内血栓形成率观察组显著低于对照组,差异有统计学意义(P<0.05),心力衰竭率、出血率、脑梗死发生率、死亡率观察组与对照组相比差异无统计学意义(P>0.05)。结论:氯吡格雷治疗急性心肌梗死是安全有效的。
Objective: To evaluate the effectiveness and safety of the treatment of acute myocardial infarction(AMI) with clopidogrel.Methods: 107 patients(68 males and 39 females,with AMI within 12 hours) without contraindication for thrombolytic therapy were divided into two groups: observation group(n=44) and control group(n=63).The patients of two groups all accepted enteric oral Aspirin,intravenous thrombolytic therap.with Urokinase and subcutaneous injection with low-molecular-weight heparin calcium after thrombolytic therapy 12 h later,and the observation group added 300 mg Clopidogrel and 75 mg once daily after the first day.The rate of patency of infarct-related anery(IRA),intracoronary thrombus,re-infarction after therapy,hemorrhagic complications,mortality and post-infarction angina were compared and analyzed between the two groups.Results: The rate of angina,re-infarction,patency of infarct-related anery(IRA) and intracoronary thrombus in observation group were obviously lower than those in control group(P<0.05).There was no significant difference in the rate of heart failure,hemorrhagic complications,cerebral infarction,and mortality in both groups(P>0.05).Conclusion: The treatment of acute myocardial infarction with clopidogrel is safe and effective.
出处
《中国医药导报》
CAS
2011年第21期146-147,共2页
China Medical Herald
关键词
氯吡格雷
心肌梗死
临床观察
Clopidogrel
Myocardial infarction
Clinical observation
