摘要
目的分析甲状腺功能亢进(简称甲亢)患者治疗前后血清脂联素(adiponectin,ADPN)和游离脂肪酸(free fatty acid,FFA)水平变化,探讨其与甲亢发生、发展过程中的相关性。方法对甲亢患者初诊组32例,复诊组32例(经他巴唑治疗时间大于1年),对照组20名(健康体检人群),进行血清ADPN、FFA、空腹血糖(fastingblood-glucose,FBG)和糖化血红蛋白(glycolated hemoglobin,GHb)检测分析。结果 (1)血清ADPN和FFA水平:甲亢患者明显高于对照组,且治疗前明显高于治疗后(P<0.05);(2)FBG水平:甲亢患者明显高于对照组(P<0.05),且其治疗前后差异无统计学意义(P>0.05);(3)GHb水平:甲亢患者治疗前后与对照组均差异无统计学意义(P>0.05)。结论 (1)甲亢治疗前后ADPN和FFA水平存在差异,甲亢的药物治疗对患者血清ADPN和FFA水平有下调作用,其产生及下降的机制尚有待进一步的研究。(2)检测血清ADPN和FFA水平对甲亢患者的诊断和预后具有重要价值。
Objective To analyze the change of serum adiponectin（ADPN） and free fatty acid（FFA） levels in untreated and treated hyperthyroidism patients and investigate the correlation of serum ADPN and FFA levels in the initiation and progression of hyperthyroidism.Methods We collected 32 samples with untreated hyperthyroidism,32 samples with treated hyperthyroidism（the treated time of tapazole 1 year） and 20 samples of healthy physical examineers.All samples were measured for serum ADPN,FFA,fasting blood glucose（FBG） and glycolated hemoglobin（GHb）.Results（1） Serum ADPN and FFA levels of patients with hyperthyroidism were higher than those of control one（P0.05）,and those of untreated patients were higher than those of treated ones（P0.05）;（2）FBG level of patients with hyperthyroidism were higher than that of healthy volunteers（P0.05） and there were no significant difference between the the patients with untreated and treated hyperthyroidism（P0.05）;（3）GHb level between the hyperthyroidism patients and the control group was not significantly different（P0.05）.Conclusion（1）ADPN and FFA levels of patients with hyperthyroidism are different before and after treatment,and the concentration of ADPN and FFA is reduced by drug therapy,and mechanism of origination and fall needs us to further study.（2） The detection of ADPN and FFA has high value for diagnosis and prognosis of the patients with hyperthyroidism.
出处
《检验医学与临床》
CAS
2011年第15期1823-1824,共2页
Laboratory Medicine and Clinic
