摘要
目的探讨实验室肿瘤特异性生长因子(TSGF)和甲胎蛋白(AFP)血清水平联合测定,在原发性肝癌(PLC)诊断中的应用价值。方法对65例经影像学检查及组织活检确诊的PLC患者,60名普通健康人群,用TS-GF诊断试剂盒和AFP荧光免疫标记定量方法进行血清TSGF和AFP的定量测定,并进行统计学的相关处理分析。结果 PLC患者血清TSGF和AFP浓度明显高于健康对照组,P<0.01,差异有统计学意义;在患者组中,以血清TSGF≥65U/mL、AFP≥11μg/L为阳性判断值,TSGF阳性率为86.15%,AFP阳性率为73.85%,TSGF和AFP联合检测(其中一项或二项全部为阳性)阳性率为95.38%。结论 TSGF和AFP在原发性肝癌中有很高的血清水平表现,具有很好的诊断应用价值,其中TSGF是一项较AFP更为敏感的肿瘤标志物,特别是对AFP阴性或低浓度患者,二者联合检测可明显提高PLC诊断的阳性率。
Objective To discuss the diagnosis value of the combined detection of laboratory tumor specific growth factor（TSGF） and alpha feta protein（AFP） on the primar liver cancer（PLC）.Methods 65 PLC patients diagnosed by image examination and biopsy,and 60 health people were collected,then the serum levels of TSGF and AFP were tested by TSGF diagnostic kit and AFP marked quantitative fluorescent immune method,and we analyzed the relevant statistics.Results The serum TSGF and AFP concentrations of patients with PLC were higher than those of the health controls,with significant difference（P0.01）.A remarkable differentiated in the group of patients,TSGF≥65 U/mL,AFP≥11 μg/L were the positive standards,and the positive rates of TSGF and AFP were 86.15%,73.85%,respectively.And the positive rate of combined detection of TSGF and AFP was 95.38%.Conclusion The performance of TSGF and AFP in primar liver carcinoma is very high,it is of best value in the diagnosis.The sensitivity of TSGF is higher than that of AFP as a tumor marker,especially in the patients with low concentration of AFP or negative AFP.The combined detection may increase the diagnostic rate of PLC.
出处
《检验医学与临床》
CAS
2011年第15期1839-1840,共2页
Laboratory Medicine and Clinic
关键词
肿瘤特异性生长因子
甲胎蛋白
联合检测
原发性肝癌
应用价值
tumor specific growth factor
alpha feta protein
combined detection
primar liver carcinoma
application value
