摘要
目的观察甘精胰岛素(来得时)联合口服降糖药治疗2型糖尿病的临床疗效。方法对47例单用口服降糖药效果欠佳的2型糖尿病患者睡前(22时)加用甘精胰岛素分别测定治疗3个月前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹C肽、餐后2hC肽,血脂、体重。结果加用甘精胰岛素治疗3个月后,患者的FPG、2hPG、HbA1c较治疗前明显下降(P<0.01),餐后2hC肽较治疗前明显升高,其差异有统计学意义(P<0.01),而对血脂、体重指数影响不大。结论对单用口服药效果不佳的2型糖尿病,加用甘精胰岛素治疗效果显著。
Objective The observation of the effect of the insulin glargine（Lantus）combined with oral hypoglycemic agents in the clinical treatment of type 2 diabetes patients.Methods 47 patients with oral hypoglycemic agents alone is ineffective in type 2 diabetes.Patients bedtime（22 pm）plus insulin glargine treatment were measured before and after 3 months fasting plasma glucose（FPG）.Postprandial 2 h blood glucose（2 hPG）,glycosylated hemoglobin（HbA1c）,fasting C peptide,2-hour postprandial C peptides,lipids,body weight.Results The addition of insulin glargine after 3 months of treatment,the patient＇s FPG,2 hPG,HbA1c decreased significantly than that before treatment（P0.01）,2-hour postprandial C peptide was significantly higher than that before treatment,the difference was significant（P0.01）,while the fat,body mass index had little effect.Conclusion The effect of poor oral medication alone in type 2 diabetes,insulin glargine plus a significant treatment effect.
出处
《中国实用医药》
2011年第21期63-64,共2页
China Practical Medicine
关键词
甘精胰岛素
口服降糖药
2型糖尿病
Insulin glargine
Oral hypoglycemic agents
Type 2 diabetes
