摘要
目的通过不同浓度氟化钠对大鼠尿氟、血氟、牙氟、骨氟以及对下切牙体视显微镜的观察,分析氟离子代谢对氟斑牙形成的影响。方法将Wistar雌性大鼠随机分为5组,分别以0、25、50、100、150 mg/L氟离子饲水喂养6个月,测定尿、血、牙、骨氟离子浓度及对下切牙进行体视显微镜观察。结果 150 mg/L组从第8周开始,体重增长趋势逐渐减弱,与空白组比较,差异有统计学意义(P<0.05);各染氟组尿氟、骨氟和牙氟与空白组相比较,氟离子浓度值明显升高,差异有统计学意义(P<0.05);染氟组血氟均有不同程度升高,但差异无统计学意义(P>0.05)。结论氟斑牙出现的时间和轻重程度与染氟时间和剂量呈正相关关系,氟斑牙体视显微镜下病变程度更加明确;尿氟、骨氟及牙氟与氟斑牙的形成和进展呈正相关关系;血氟变化与氟斑牙形成关系不明确。
Objective To examine the influence of fluorine ion metablism on the formation of fluorotic teeth by observ ations of the changes of urine fluorine,blood fluorine,fluorine in bone,and tooth slice after exposures to different concentrations of sodium fluoride in rat.Methods Wistar female rats were randomly divided into 5 groups which exposed to 0,25,50,100,and 150 mg/L fluorine ion in drinking water for 6 months.The fluorine ion concentration of urine,blood,teeth,and bone were determined and the slice of teeth were observed with microscope.Results The increase of body weight weakened gradually after 8 weeks＇ exposure to fluorine ion of 150 mm/L with a significant difference compared with that of rats in contorl group（P0.05）.The contents of urine,bone and teeth fluorine increased significantly compared with those of the controls（P0.05）.Conclusion The occurrence and severity of fluorotic teeth were positively correlated with the time and dose of fluorine ion exposure.Urine,bone,and tooth fluorine and fluorotic teeth formation were positively correlated.No difinite relationship was observed between blood fluorine change and fiuorotic teeth formation.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2011年第8期1000-1001,共2页
Chinese Journal of Public Health
基金
国家自然基金(30860249)
关键词
氟离子
氟斑牙
代谢
fluorine ion
fluorotic teeth
metabolism
