摘要
目的探讨NSE、CYFRA21-1、CA125三种肿瘤标志物联合检测在肺癌诊断中的价值。方法采用电化学发光法(ECLIA)检测56例肺癌,30例肺良性疾病和30例健康体检者血中神经元特异性烯醇化酶(NSE)、细胞角蛋白21-1(CYFRA21-1)、糖类抗原125(CA125)的含量。结果肺癌组血中NSE、CYFRA21-1、CA125的含量明显高于肺良性病变组和正常对照组,差异具有统计学意义(P<0.05)。NSE、CYFRA21-1、CA125对肺癌的敏感性分别为80.3%、78.6%、91.1%;三项联检敏感性可达95.8%,准确性可达85.3%。结论联合检测可明显提高肺癌的敏感性和准确性。为早期诊断早治疗提供有力的证据。
Aim To observe the clinical value of combined determination of three serum markers for diagnosis of lung cancer. Methods The electrochemiluminescence （ECLIA） was adopted to detect the serum level of NSE, CYFRA21-1 and CA125 in 56 patients with lung cancer,30 patients with benign pulmonary diseases and 30 healthy persons. Results The levels of the serum markers in lung cancer group were significantly higher than patients with benign lung disease and healthy controlls. Tile sensitivities of diangnosis of lung cancer by determination of NSE,CYFRA21-1 and CA125 were 80.3%,78.6% and 91.1%,respectively. The sensitivity for combined detection of NSE, CYFRA21-1 and CA125 was 95.8%, significantly higher than single assay. Conclusion The combined detection of NSE,CYFRA21-1 and CA125 can significantly improve sensitivity and accuracy in diagnosis of lung cancer and might provide valuable laboratory evidence for early diagnosis and treatment of lung cancer patients.
出处
《中国热带医学》
CAS
2011年第7期880-882,共3页
China Tropical Medicine
