摘要
目的探讨乌拉地尔复合艾司洛尔用于高血压患者眼-鼻相关微创手术中控制性降压的临床效果和安全性。方法选择60例择期行鼻内窥镜下眼-鼻相关手术的高血压病患者,随机分成A组(乌拉地尔)、B组(乌拉地尔复合艾司洛尔),n=30。记录降压前后血流动力学变化,同时记录术中晶胶体输入量、尿量、输血量和出血量;两组病人开始降压时间,停药后血压回升时间,并进行Fromme术野质量评分和围术期并发症观察。结果 B组在降压后30、60min时HR、MAP和心肌耗氧量(RPP)低于A组(P<0.05)。B组开始降压时间与A组相比有统计学意义(P<0.05);B组30、60min时的Fromme术野质量评分与A组相比有统计学意义(P<0.05)。结论乌拉地尔复合艾司洛尔实施控制性降压用于高血压患者降压效果明显优于单用乌拉地尔,出血少术野清晰,安全可靠,具有较高的临床应用价值。
OBJECTIVE To investgate the effect and safety of urapidil combined with esmolol control hy- potension on eye-nose related minimally-invasive surgery in hypertension patient. METHODS For 60 hypertension patients who would undergo the endoscopic sinus eye-nose related minimally-invasive surgery, randomly divided into group A （Urapidil）,group B（Urapidil combined with esmolol）, n = 30.The hemodynamics change were record, The liquid input,urine volume, blood transfusion, bleeding volume, the time of blood pressure fall and recovery were record, meanwhile, Fromme score of operative field quality （FS-OFQ） was evaluated, and the complication of control hypotension during the operatin were observed. RESULTS The rate-pressure product（PPR）, HR and MAC in group B after control hypotension 30,60rain were significantly change as compared those in group A （P 〈 0.05） ;Fromme score of operative field quality in group A aftert control hypotenion 30,60min were significantly higher compared those in group B and group C（P 〈 0.05）. The time of blood pressure fall in group A was longer than group B（P〈0.05）.CONCLUSION Urapidil combined with esmolol was better and more safe compare with single Urapidil control hypotension in hypertension patient. And it was clear surgical field and clinical value.
出处
《海峡药学》
2011年第7期95-97,共3页
Strait Pharmaceutical Journal
关键词
控制性降压
乌拉地尔
艾司洛尔
高血压
眼.鼻相关微创手术
Controlled hypotension
Urapidi!
EsmoIo
Hypertension
Eye-nose related minimally-invasive surgery
