摘要
以天冬氨酸为单体合成了聚天冬酰胺，用不同长度的羟烷基作为侧链基制成聚－α、β－（羟烷基）－ＤＬ－天冬酰胺。用红外光谱法，差热分析法对材料进行了表征；对材料的急性毒性、稳定性等作了研究，实验表明该类材料为低毒性材料，并有较好的稳定性。以乙酰水杨酸为模型药物，大白兔为实验动物进行体内释放实验，结果证明侧链基越长，释药速率加快。
A water soluble polymer α,β poly (hydroxyalkyl) DL asparamide was synthesized by polysuccinimide(PSI) and different lengths of hydroxyalkyls, including α,β poly(hydroxyethyl) DL asparamide(PHEA),α,β poly(hydroxypropyl) DL asparamide(PHPA),and α,β poly(hydroxybutyl) DL asparamide(PHBA). These polymers were characterized by differential scanning calorimetry(DSC) and infrared spectrophotometry(IR). Stability and acutetoxicity of these polymers were studied. The experiment indicated that these materials were of low toxicity and high stability. Acetylsalicylic acid, as a model drug, was conjugated into polymers; the drug loadings were 38.63%, 37.68% and 38.70% respectively. Polymer drugs were made into cylinder, and in vivo release in rabbits was set out. It showed that the longer the spacer was linked into the polymer, the faster the drug was released.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1999年第4期429-434,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金!资助项目(39570219)
关键词
聚天冬酰胺
羟烷基
乙酰水杨酸
体内释放
Polysuccinimide(PSI)
Hydroxyalkyl
Acetylsalicylic acid
In vivo release
