摘要
目的观察强迫症患者治疗前后心率变异性的改变。方法符合CCMD-3强迫症诊断标准的68例患者口服马来酸氟伏沙明治疗,治疗前后进行心率变异性检查。结果强迫症组治疗前的心率变异性总功率(TP)、高频功率(HF)指标均低于正常对照组,差异有统计学意义(P<0.01),低频功率/高频功率强迫症组治疗前高于正常对照组,差异具有统计学意义(P<0.05)。强迫症组治疗后的TP、LF指标与正常对照组相比较,差异无统计学意义;HF指标较治疗前数值虽有所增加,但仍低于正常对照组,差异有统计学意义(P<0.05);LF/HF值仍稍高于正常对照组,差异有统计学意义(P<0.05)。强迫症组治疗前后自身比较,治疗后TP、HF值增高,LF/HF值降低,差异具有统计学意义(P<0.05)。结论强迫症患者自主神经功能紊乱,主要是迷走神经功能降低,交感神经功能亢进。经马来酸氟伏沙明治疗后,自主神经功能趋于协调。
Objective To observe the change of heart rate variability in obsessive compulsive disorder patient.Methods Six-eight patients before treatment and 60 health adults were enrolled our study,spectrum analysis of heart rate variability（HRV） was carried out on each case under resting state.After 12-week treatment,HRV was carried out again.Results Compared with normal control group,the power of obsessive compulsive disorder group was obviously decreased,there was a significant difference,and haplotype frequency was obvious lower than normal control group（P0.05）.After 12-week treatment,the power was obviously increased（P0.05）.Conclusion Autonomic nerve functional disorder of obsessive compulsive disorder patient is mainly caused by degrades of vagus nerve function and hyperfunction of trisplanchnic nerve.After treatment,vagus nerve function is higher and trisplanchnic nerve function is lower than before.
出处
《中国实用神经疾病杂志》
2011年第13期1-3,共3页
Chinese Journal of Practical Nervous Diseases
基金
郑州市科技局卫生科研基金资助项目(编号:083SGYS33249)
关键词
强迫症
心率变异性
频谱分析
Obsessive compulsive disorder（OCD）
Heart rate variability（HRV）
Spectrum analysis
