摘要
目的探讨急性脑梗死(ACI)患者血清超敏C反应蛋白(hs-CRP)和补体3(C3)的表达及意义。方法检测98例ACI患者及30例正常对照者的血清C3和hs-CRP含量,在ACI组中比较不同病情、不同梗死面积ACI患者的血清C3和hs-CRP含量变化,并对C3和hs-CRP之间的关系进行相关性分析。结果 ACI组血清C3和hs-CRP的含量明显高于正常对照组(均P<0.01),ACI病情重度组、大面积梗死组血清C3和hs-CRP的含量明显高于病情中度、轻度组和小面积、腔隙性脑梗死组,病情中度组、小面积梗死组又明显高于病情轻度组、腔隙性脑梗死组(均P<0.05)。血清C3和hs-CRP含量呈正相关(r=0.798,P<0.01)。结论血浆hs-CRP及C3与ACI的发生、发展、严重程度及预后有关,ACI高危人群及ACI患者应常规检测血浆hs-CRP及C3水平。
Objective To investigate the changes and their significance of high-sentivity C-reactive protein（hs-CRP） and serum complement 3（C3） in patients with acute cerebral infarction（ACI）.Methods The content of hs-CRP and C3 in 98 patients with ACI and 30 normal controls were measured.The contents of serum C3 and hs-CRP were compared in the patients of different pathogenetic condition and infarction size.The correlation between serum C3 and hs-CRP and pathogenetic condition and infarction size were analyzed.Results The contents of serum C3 and hs-CRP in ACI group were significantly higher than normal control group（all P0.01）.The contents of serum C3 and hs-CRP in the patients with serious state of illness and large size infarction were significantly higher than those in the middle-light state of illness and small size or lacuna infarction groups,the patients with middle state of illness,small size infarction were significantly higher than those in the light state of illness and lacuna infarction groups（all P0.05）.The content of serum C3 had positive correlation with the content of hs-CRP（r=0.798,P0.01）.Conclusion The contents of serum C3 and hs-CRP increase in the patients with ACI,and are correlated with the illness state and infarction size,which register that serum C3 and hs-CRP are the indexes of serum biology in ACI condition.
出处
《中国实用神经疾病杂志》
2011年第13期5-8,共4页
Chinese Journal of Practical Nervous Diseases
关键词
急性脑梗死
补体3
超敏C反应蛋白
Acute cerebral infarction
Complement 3
High-sensitivity C-reactive protein
