摘要
目的探讨观察不同人群脂蛋白a[lipoprotein a,Lp(a)]的水平及他汀类药物对其的干预效果。方法符合高血脂诊断标准的42例冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者(高血脂合并CHD组),36例CHD合并2型糖尿病(type 2 diabetes mellitus,2TD)患者(高血脂合并CHD+2TD组),39例非CHD非2TD患者(对照组)接受他汀类药物治疗8周,于治疗前后测定Lp(a)及低密度脂蛋白浓度,并进行数据统计。结果高血脂合并CHD组及高血脂合并CHD+2TD组的血清Lp(a)浓度均显著高于对照组,差异有统计学意义[(37.1±11.6)mmol/L vs.(26.6±4.2)mmol/L,P<0.05;(39.4±10.7)mmol/L vs.(26.6±4.2)mmol/L,P<0.05];而高血脂合并CHD组与高血脂合并CHD+2TD组比较,差异无统计学意义(P>0.05)。他汀类药物治疗后3组患者的血清Lp(a)浓度均较治疗前有显著下降,高血脂合并CHD+2TD组下降最明显,差异均有统计学意义[(28.1±7.3)mmol/L vs.(37.1±11.6)mmol/L,P<0.05;(26.1±6.8)mmol/L vs.(39.4±10.7)mmol/L,P<0.05;(26.6±4.2)mmol/L vs.(21.2±6.3)mmol/L,P<0.05]。结论 CHD患者的血清Lp(a)浓度高于非CHD患者,他汀类药物可显著降低血清Lp(a)的浓度,在合并2TD的CHD患者中降低更明显。
Objectives To observe the lipoprotein a [ Lp （a） ] levels in different groups of people and effect of statins on Lp （a） in patients with coronary heart disease. Methods According to the hyperlipemia diagnostic criteria, 42 patients with simple standard coronary heart disease （hyperlipemia combinded with CHD group）, 36 cases of type 2 diabetes mellitus （2TD） patients with CHD （hyperlipemia combinded with CHD ＋2TD group）, 39 non-CHD and non- 2TD subjects （control group） received statin therapy for 8 weeks. Secrum concentrations of Lp （a） and low density lipoprotein before and after treatment were measured, and the data were analyzed. Results Secrum concentrations of Lp （a） in hyperlipemia combinded with CHD group and hyperlipemia combinded with CHD ＋2TD group were significantly higer than that in control group before treatment [ （37.1 ± 11.6） mmol/L vs. （26.6±4.2） mmol/L, P〈0.05 ; （39.4±10.7） mmol/L vs. （26.6±4.2） mmol/L, P〈0.05 ], but the difference was not significant between hyperlipemia combinded with CHD group and hyperlipemia combinded with CHD＋2TD group （P〉0.05）. Secrum concentrations of Lp （a）significanfly decreased after treated with statins among the 3 groups~ expecially in hyperlipemia combinded with CHD＋2TD group [ （28.1±7.3） mmol/Lvs. （37.1±11.6） mmol/L,P〈0.05; （26.1±6.8） mmol/L vs. （39.4±10.7） mmol/L, P〈0.05; （26.6±4.2） mmol/L vs. （21.2±6.3） mmol/L, P〈0.05]. Conclusions Serum concentration of Lp （a） in patients with CHD are higher than that in non-CHD people. Statins can significantly reduce the level of Lp （a）, especially in patients with CHD combined with 2TD.
出处
《岭南心血管病杂志》
2011年第4期285-287,336,共4页
South China Journal of Cardiovascular Diseases
