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中青年缺血性脑卒中患者抗心磷脂抗体与血小板聚集率的关系 被引量：7

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摘要 目的探讨中青年缺血性脑卒中患者抗心磷脂抗体(ACA)与血小板聚集率(PAgT)的关系。方法选择72例中青年缺血性脑卒中患者(卒中组)及89例查体健康者(对照组),两组性别、年龄及传统卒中危险因素匹配;检测两组ACA、PAgT,分析二者的相关性。结果卒中组ACA阳性率及PAgT水平均明显高于对照组(P均<0.01),卒中组的ACA与PAgT水平呈正相关(r=0.821,P<0.01)。结论 ACA为中青年缺血性脑卒中发病的独立危险因素,及时检测ACA、PAgT对预防、评估脑卒中有积极意义,二者联合检测有利于脑卒中的早期防治。
作者 李贞洁 杨晓红 陈首英
机构地区 河北大学附属医院 河北大学医学部预防医学系
出处 《山东医药》 CAS 北大核心 2011年第25期32-33,共2页 Shandong Medical Journal
关键词 脑血管疾病 中青年 抗心磷脂抗体 血小板聚集率
分类号 R743 [医药卫生—神经病学与精神病学]
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  • 1NigelChoon-kiattan,N,Venketasubramanian,Seang-MeiSaw,et al.Hyperhomocysteinemia and Risk of Ischemic stroke among young Asian adults.Stroke,2002,33:1956.
  • 2Soler-Gonzalez R,Munonz_Torrero JJ,Dominguezf,et al.Analysis of the echocardiographic findings in young patients with cere ischemia.Rev Neurol,1999,29(10):972.
  • 3Siqueria Neto JI,Santos AC,Fabio SR,et al.Antipholipid antibody in 66 patients with cerebral infarction between 15 and 40 years old.Arq Neuropsiquiatr,1996,54(4):584.
  • 4Geaves M. antiphospholipid antibodies and thrombsis. Lancet. 1999: 353:1348-1353
  • 5Simantov R, Lo SK, Gharavi A, et al. Antiphospholipid antibodies actuate vascular endothelial cells. Lupus. 1996; 5 (5): 440-441
  • 6Fields RA, Sibbitt WL, Toubbeh H, et al. Neuropsyehiatrie lupus erytbe-matosus, cerebral infarctions, and anticardiolipin antibod ies. Ann Rheum Dis. 1990; 49: 114
  • 7Schorer AE, NickhamNW, Warson W, et al. Lupus anticoagulant induces a selective defect in thrombin-mdeiated endothelial prostacyclin release and platelet aggregation. Br J Haematol. 1989: 71: 399
  • 8Harper MF, Haves PM, Lents BR, et al. Characterization of beta2- glycoprotein Ⅰ binding phospholipid membranes. Thromb Haemost. 1998,80(4): 610-4
  • 9Rand iH. Molecular pathogenesis of the antiphospholipid syndrome. Circ Res. 2002,90: 29-37
  • 10Faioni EM, Razzari C, Martinelli I, et al. Resistance to activated protein C in unseleeted patients with arterial and venous thrombosis. Am J Hematol. 1997,55:59-64

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  • 1谭兵兵,王乾兴,谭晓珊,刘华庆.胎盘绒毛血管生成状况及VEGF、MMP-2和MMP-9表达与早期自然流产的关系[J].生殖与避孕,2006,26(8):477-482. 被引量：26
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33037
  • 3王艳玲,吴华香.抗磷脂综合征与妊娠丢失的研究进展[J].中国妇幼健康研究,2007,18(1):44-46. 被引量：8
  • 4Chandrashekhara S, Kirthi R, Varghese J. Prevalence of anticardiolipin antibodies in various thrombotic conditions: a hospital-based study [ J ]. Assoc Physicians India, 2003,51 ( 4 ) : 359 -362.
  • 5Kayaba H, Hebiguchi T, Itoh Y, et al. Evaluation of anorectal function in patients with tethered cord syndrome:saline enema test and feco- flowmetry [ J ]. J Neurosurg : Spine,2003,98 (3) :251-257.
  • 6Bhattacharyya M,Kannan M,Biswas A,et al. [32 glycoprotein 1 in In- dian patients with SLE [ J ]. Clin Appl Thromb Hemost,2005,11 (2) : 223-226.
  • 7Ortel TL. The antiphospholipid syndrome:what are we really measur- ing? How do we measure it? And how do we treat it? [J]. J Thromb Thrombolysis,2006,21 ( 1 ) : 79-83.
  • 8Pasquali JL, Nehme H, Korganow AS, et al. Antiphospholipid antibod- ies : recent progresses on their origin and pathogenicity [ J ]. Joint Bone Spine,2004,71 ( 3 ) : 172-174.
  • 9Rodriguez V, Reed AM, Kuntz NL, et al. Antiphospholipid syndrome with catastrophic bleeding and recurrent isehemic strokes as initial presentation of systemic lupus erythematosus [ J ]. J Pediatr Hematol Oneol, 2005,27 ( 7 ) :403-407.
  • 10Dutta A, Mukherjee B, Das D, et al. Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to bi- omass smoke during cooking[J]. Indoor Air,2011,21 (2) :165-176.

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山东医药
2011年 第25期

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