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Caveolin-1在卵巢上皮性腺癌组织中的表达及意义 被引量：3

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摘要 目的:研究caveolin-1在卵巢上皮性腺癌(以下简称为卵巢癌)组织中的表达情况,探讨其在卵巢癌发生发展中的作用机制。方法:用S-P免疫组化技术检测15例正常卵巢组织、38例卵巢上皮性良性肿瘤组织、20例上皮性交界性肿瘤组织和38例卵巢癌组织中caveolin-1的表达,分析其在卵巢癌组织中的表达与肿瘤病理级别之间的关系。结果:相对于正常卵巢组织,caveolin-1在卵巢癌组织中表达明显降低(P<0.0001),且随细胞分化程度降低而减少(P<0.05),随临床分期的增加而降低(P<0.01),伴有区域性淋巴结转移者,caveolin-1表达降低,但差异无显著性(P>0.05)。结论:Caveolin-1的表达降低与卵巢癌的生物学行为密切相关;caveolin-1的表达异常在上皮性卵巢恶性肿瘤发生发展过程中起着重要作用。
作者 曾琼 遇桂芳 左艳 李玉英 杨静 叶延清
机构地区 暨南大学医学院附属珠海医院妇科
出处 《实用医学杂志》 CAS 北大核心 2011年第17期3144-3146,共3页 The Journal of Practical Medicine
基金 珠海市卫生局立项资助课题(编号:A2009637)
关键词 卵巢肿瘤 CAVEOLIN-1 发病机制
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献12

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同被引文献29

  • 1李宁,邓文英,马懿辉,陈小兵,韩黎丽,罗素霞.β-catenin、干细胞标志物Sox-2表达与结肠癌术后复发转移的关系[J].中华临床医师杂志（电子版）,2011,5(22):6585-6589. 被引量：4
  • 2梁菲,姜洁,李少儒,刘洋,李卫华,程世杰,成磊.小窝蛋白-1在卵巢癌组织中表达及其预后意义[J].肿瘤,2010,30(11):950-954. 被引量：1
  • 3叶冬梅,陈琛,邵淑娟.Caveolae、Caveolin-1与肿瘤的研究进展[J].解剖科学进展,2006,12(4):355-358. 被引量：3
  • 4John H. Chidlow,Joshua J.M. Greer,Christoph Anthoni,Pascal Bernatchez,Carlos Fernadez–Hernando,Megan Bruce,Maisoun Abdelbaqi,Deepti Shukla,D. Neil Granger,William C. Sessa,Christopher G. Kevil.Endothelial Caveolin-1 Regulates Pathologic Angiogenesis in a Mouse Model of Colitis[J].Gastroenterology.2009(2)
  • 5Liang QL, Wang BR, Li ZY,et al. Effect of TSLC1 gene on growth and apoptosis in human epsophageal carcinoma E- cal09 ceils [J]. Arch Med Sci, 2012,8:987-992.
  • 6Schubert W, Frank PG, Razani B, et al. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo [J]. J Biol Chem,2001,276(52) :48619- 48622.
  • 7Calizo RC,Scarlata S. A role for G-proteins in directing G- proteincoupled receptor-caveolae localization [J]. Biochem- istry,2012,51 (47) :9513-9523.
  • 8Drab M, Verkade P, Elger M, et al. Loss of caveolae,vas- cular dysfunction,and pulmonary defects in caveolin-1 gene-disrupted mice [J]. Science,2001,293 (5539) :2449- 2452.
  • 9Satoh T,Yang G,Egawa S,et al. Caveolin-1 expression is a predictor of recurrence free survival in FIEN0 prostate carcinoma diagnosed in Japanese patients [J]. Cancer, 2003,97 (5) : 1225-1233.
  • 10Fong A, Garcia E, Gwynn L,et al, Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differ- entiation [J]. AmJ Clin Patho1,2003,120( 1 ):93-100.

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实用医学杂志
2011年 第17期

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