摘要
目的:制备塞来昔布(CLX)脂质体,并对其抗肿瘤活性进行初步研究。方法:采用薄膜分散法制备CLX脂质体,均匀设计筛选最佳处方及制备工艺。采用动物移植性肿瘤实验法,用小鼠H22肝癌细胞接种于小鼠右侧腋下皮下形成实体瘤,考察CLX脂质体和同剂量CLX溶液给药后对实体瘤的瘤重抑制率。结果:CLX脂质体的平均粒径为(369.5±10.8)nm,平均包封率为(81.6±2.2)%(n=3);CLX脂质体对小鼠H22肝癌移植瘤的抑瘤率为68.2%,显著高于CLX溶液的抑瘤率(46.5%)(P<0.05)。结论:CLX脂质体制备简单,并具有较好的抗肿瘤活性。
OBJECTIVE To prepare celecoxib （CLX） liposomes and study its anti-tumour activity. METHODS CLX liposomes were prepared by film dispersion method. The animal model of implantation solid tumor was applied to evaluate the antitumor effect of CLX liposomes and CLX solution by subcutaneous injection of murine hepatoma cells （H22） into the right limb armpit of mice. RESULTS Mean diameter of the CLX liposomes was （369. 5 ＋ 10. 8） nm and average entrapment efficiency was （81.6 ± 2. 2） % （n = 3）. The rate of inhibitory effect on tumor restrain of CLX liposomes was 68.2% which was remark ably higher than that of the CLX solution （P〈0. 05）. CONCLUSION CLX liposomes can be prepared easily with promising anti-tumor effect.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第15期1251-1254,共4页
Chinese Journal of Hospital Pharmacy
关键词
塞来昔布
脂质体
H22肝癌
肿瘤抑制率
celecoxib
liposomes
H22 hepatocarcinoma
inhibitory rate on tumor
