摘要
目的探讨联合检测尿微量白蛋白(mAlb)、N-乙酰-D-氨基葡萄糖苷酶(NAG-ase)水平对糖尿病肾病(DN)早期诊断的价值。方法采用免疫透射比浊法检测80例糖尿病患者的mAlb和NAG-ase的水平,并与对照组60例健康人进行比较,对结果进行统计分析。结果病程<5年的糖尿病患者的mAlb、NAG-ase与健康对照组比较差异无统计学意义(P>0.05);病程5～10年的患者与健康对照组比较,mAlb、NAG-ase差异有统计学意义(P<0.01);病程>10年的患者mAlb、NAG-ase明显高于健康对照组,差异有统计学意义(P<0.01)。随着年龄的增长,患者的mAlb、NAG-ase浓度也逐渐增加。结论 mAlb、NAG-ase联合检测对糖尿病肾病的早期诊断有非常重要的临床参考价值,可作为糖尿病肾病的早期诊断指标。
Objective To investigate the early diagnostic value of the combined detection of urine microamount albumin（mAlb） and N-β-D-glucosaminidase（NAG-ase） for diabetic nephropathy.Methods Urine mAlb and NAG-ase levels were examined with immunoturbidimetry in 80 di-abetics and 60 healthy subjects.The results were compared between patients and healthy controls and analyzed statistically.Results No difference inurine mAlb and NAG-ase between patients with diabetes less than 5 years and healthy control was found（P 0.05）;however,significant differencesin mAlb and NAG-ase levels between patients with diabetes 5-10 years and healthy control were detected（P 0.05）,and mAlb and NAG-aselevels in patients with diabetes more than 10 years were obviously higher than healthy control（P 0.05）.In addition,urine mAlb and NAG-ase increased gradually with age.Conclusion The study suggests that the combined detection of MAlb and NAG-ase may act as indicator for the early diagnosis of diabetic nephropathy.
出处
《临床和实验医学杂志》
2011年第15期1146-1147,共2页
Journal of Clinical and Experimental Medicine
