摘要
目的：探讨胰腺癌患者围手术期机体免疫功能的变化。方法：动态观察４０例胰腺癌患者围手术期外周血Ｔ淋巴细胞亚群、红细胞免疫功能指标ＲＢＣ－Ｃ３ｂＲ和ＲＢＣ－ＩＣＲ、以及体液免疫指标ＩｇＧ，ＩｇＡ和ＩｇＭ。结果：胰腺癌患者术前ＣＤ３，ＣＤ４，ＣＤ４／ＣＤ８比值及ＲＢＣ－Ｃ３ｂＲ均明显降低，ＣＤ８ 和ＲＢＣ－ＩＣＲ明显增高，血清免疫球蛋白ＩｇＧ水平也呈升高趋势。其中Ｔ淋巴细胞亚群与红细胞免疫功能指标的变化具有一定的相关性。与胰腺癌未切除组相比，胰腺癌切除组手术后２ 周Ｔ淋巴细胞亚群、红细胞免疫功能指标和血清免疫球蛋白ＩｇＧ逐渐趋于恢复，术后３０ ｄ 基本恢复正常。结论：胰腺癌患者的免疫系统均有不同程度的损害，手术治疗有助于机体免疫功能的恢复。此外，对肿瘤患者免疫状态的观察不仅包括白细胞免疫系统，还应注重对红细胞免疫的监测。
Objective: To investigate the changes of immune function in patients with pancreatic cancer. Methods: The T lymphocyte subgroup, the immune function of red blood cell and serum immunoglobulin of 40 patients with pancreatic cancer during preoperative and postoperative period were observed dynamically. Results: CD3, CD4, CD4/CD8 ratio and RBC C3bR were significantly decreased preoperatively, while CD3 and RBC ICR were increased markedly. The level of serum IgG was also higher than normal. The changes of T lymphocyte subgroup were significantly associated with immune function of red blood cells. The T lymphocyte subgroup and the immune function of red blood cell in patients received radical treatment recovered gradually 2 weeks after operation and showed nearly the normal level after 30 d postoperatively. Conclusion: The immune function system in patients with pancreatic cancer is defected to different degrees. Operative treatment can recover the immune function in these cases. On the other hand, the investigation of immune system in patients with cancer consists not only of granulocyte immune system but also the blood cell immune system.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第11期889-891,共3页
Academic Journal of Second Military Medical University
关键词
胰腺肿瘤
T细胞亚群
红细胞免疫
免疫球蛋白
pancreatic neoplasms
T lymphocyte subgroup
red blood cell immune function
immunoglobulin
intraoperative period
