摘要
目的:观察前列地尔注射液联合甘草酸二胺注射液治疗淤胆型病毒性肝炎的临床疗效及其安全性。方法:将我院64例淤胆型肝炎患者随机分成治疗组(34例)和对照组(30例),治疗组给予前列地尔注射液10μg加入0.9%氯化钠注射液150mL中静脉滴注+甘草酸二胺注射液150mg加入5%葡萄糖注射液200mL中静脉滴注,qd;对照组给予复方丹参注射液20mL加入5%葡萄糖注射液250mL中静脉滴注+甘草酸二胺注射液150mg加入5%葡萄糖注射液200mL中静脉滴注,qd。2组疗程均为6～8周。治疗后,观察2组临床症状恢复情况及血清总胆红素(STB)、血清直接胆红素(SDB)、碱性磷酸酶(AKP)、谷氨酰氨基转肽酶(γ-GT)的变化和不良反应发生率。结果:治疗结束后,治疗组临床症状改善率明显优于对照组,2组比较差异均有统计学意义(P<0.05);2组患者STB、SDB水平均有明显下降,与治疗前比较差异有统计学意义(P<0.05),且治疗组较对照组下降更显著,差异有统计学意义(P<0.01)。对照组不良反应发生率显著低于治疗组(P<0.05)。结论:前列地尔联合甘草酸二胺治疗淤胆型病毒性肝炎疗效显著,且不良反应轻微。
OBJECTIVE：To observe the clinical efficacy and safety of alprostadil and diammonium glycyrrizinate injection in the treatment of cholestatic viral hepatitis. METHODS： 64 patients with cholestatic viral hepatitis were randomly divided into treatment group （34 cases） and control group （30 cases）. Treatment group was given alprostadil injection 10 μg （added into normal saline 150 mL） via i.v. gtt. and diammonium glycyrrizinate injection 150 mg （added into 5% glucose 200 mL） via i.v.gtt. once a day; control group was given compound salvia miltiorrhize injection 20 mL （added into 5% glucose 250 mL） and diammonium glycyrrizinate injection 150 mg （added into 5% glucose 200 mL） via i.v. gtt once a day. Treatment course of 2 groups lasted for 6～8 weeks. The clinical symptoms and live function indexes STB, SDB, AKP and γ-GT and the incidence of adverse drug reactions were observed before and after treatment. RESULTS： After treatment, the improvement rate of clinical symptoms in treatment group were better than in control group. There was statistical difference between 2 groups （P0.05）. The levels of STB and SDB in 2 groups decreased significantly after treatment（P0.05）. The decreases of treatment group were more significant than that of control group, there was statistical difference （P0.01）. The adverse drug reaction in treatment group were higher than control group（P0.05）. CONCLUSION： Alprostadil combined with diammonium glycyrrizinate injection is effective and safe in the treatment of cholestatic viral hepatitis without obvious adverse drug reaction.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第32期3038-3039,共2页
China Pharmacy
关键词
前列地尔
甘草酸二胺
淤胆型病毒性肝炎
Alprostadil
Diammonium glycyrrizinate
Cholestatic viral hepatitis
