摘要
动脉粥样硬化和骨质疏松都是老年人的常见多发病,严重影响老年人的身心健康,而这两种疾病在临床上常相伴出现。血管钙化是动脉粥样硬化、高血压、糖尿病、血管损伤、慢性肾病和衰老等普遍存在的病理表现,易导致心肌缺血、左心室肥大和心力衰竭,引发血栓形成、斑块破裂,是心脑血管疾病高发生率和高死亡率的重要因素。近年来许多研究提示动脉粥样硬化、血管钙化和骨质疏松之间存在着共同的危险因素、信号转导途径、分子调控机制,而使其互为因果。本文就它们之间的临床联系及发病机制进行初步探讨,为临床工作提供进一步的综合防治理念。
Atherosclerosis and osteoporosis were the most common illnesses of older people, which seriously affected the health of the elderly, and the two diseases often appeared simultaneously in clinical. Atherosclerosis, hypertension, diabetes, vascular injury, chronic kidney disease and pathological aging and so on had the common pathology of vascular calcification. It easily led to myocardial ischemia, left ventricular hypertrophy and heart failure, caused thrombosis, plaque rupture, so it was an important factor for the high incidence and high mortality of cardiovascual and cerebrovascular diseases. Recently many studies suggested that there were the common risk factors, signal transduction pathways, molecular mechanism, leading to causality among atherosclerosis, vascular calcification and osteoporosis. This review on the link between clinical and pathogenesis of preliminary study for clinical work, provides further integrated control concept.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第7期621-626,共6页
Chinese Journal of Arteriosclerosis
基金
云南省自然科学基金(2009CD166)
关键词
动脉粥样硬化
血管钙化
骨质疏松
Atherosclerosis
Vascular Calcification
Osteoporosis
