摘要
内皮祖细胞是内皮细胞的前体细胞,主要来源于骨髓,既有造血干细胞的特性,又有分化为内皮细胞的潜能,参与动脉粥样硬化的进程,与心血管疾病关系密切。研究发现心血管疾病的发病率和死亡率存在着性别差异,本文就雌激素、雄激素与内皮祖细胞的关系及其机制作一综述。
Endothelial progenitor cells (EPC) mainly derived from bone marrow are the precursor of mature endothelial cell, and have the characteristics of hematopoietic stem cells as well as the potential to differentiate into endothelial cells. EPC can participate in the process of atherosclerosis, and are closely related with cardiovascular disease. Recent studies have provided increasing evidence that gender differences exist in the morbidity and mortality of cardiovascular disease. This article tries to review the effects and mechanisms of estrogen and androgen on EPC.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第9期791-794,共4页
Chinese Journal of Arteriosclerosis
基金
湖北省教育厅重点项目(D20092403)
湖北省高等学校优秀中青年科技创新团队计划(T201008)项目资助
关键词
心血管疾病
内皮祖细胞
性激素
Cardiovascular Disease
Endothelial Progenitor Cells
Sex Hormones