摘要
乳糜泻(celiac disease,CD)是患者对麸质不耐受引起小肠黏膜病变为特征的一种原发性吸收不良综合征.当遗传易感者食用含有麸质的食物后,引起机体的免疫应答,破坏小肠绒毛,引起小肠吸收不良.依据吸收不良的程度,CD的症状有个体差异,有的无症状或症状轻微,有的症状较重.典型表现为腹泻、腹痛、腹胀等消化系症状,也有的患者出现消化系外症状.血清标志物检测和小肠活检组织病理可明确诊断.此病在北美、北欧、澳大利亚发病率较高,在我国报道少见.本文就CD的流行病学、发病机制、临床表现以及诊断和治疗作一综述.
Celiac disease（CD）is a type of primary malab-sorption syndrome characterized by gluten in-tolerance and intestinal mucosal lesions.When genetically susceptible persons eat food containing gluten,their immune system responds by damaging or destroying intestinal villi to result in intestinal malnutrition.Depending on the degree of malabsorption,the symptoms of CD vary among individuals,ranging from no symptoms,few or mild symptoms,to many or severe symptoms.Some common symptoms of CD are diarrhea,abdominal pain and bloating. People with the disease may have other symptoms outside the digestive tract.Blood marker tests and small intestinal biopsy can help make a clear diagnosis.The disease is common in North Europe,North America and Australia, but is rarely reported in China.In this article, we will review the prevalence,pathogenesis, clinical manifestations,diagnosis and treatment of CD.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第19期2053-2057,共5页
World Chinese Journal of Digestology
